The second ligand of CCR10 is CCL27 (also called cutaneous T cell-attracting chemokine or CTACK) [86] which is associated most commonly with the homing of T lymphocytes to the skin [87], but is indeed expressed by IECs.
Vicari et al., "CTACK, a skin-associated chemokine that preferentially attracts skinhoming memory T cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
In fact, a significant increase in the protein levels of cutaneous T-cell-attracting chemokine (
CTACK), chemokine (C-X-C motif) ligand-16 (CXCL16), eotaxin-2, fractalkine, and Blymphocyte chemoattractant (BLC) was reported in the UCP2 gene-knockout mice [35].
Luminex multiplex panel technology was used for simultaneous measurement of a panel of the following analytes: IL6, TNF-a, IL-5, Eotaxin, FGF-basic, PDGF-bb, VEGF, IP-10, CTACK, HGF, and SCGF-b.
Other markers, such as SMRP, pOPN, previously shown as diagnostic markers for MPM, and a panel of cytokines and grow factors (IL6, TNF-a, IL-5, Eotaxin, FGF-basic, PDGF-bb, VEGF, IP-10, CTACK, HGF, and SCGF-b) were studied.
The analysis of a 48 cytokines and chemokines panel (including IL-1[beta], IL-1ra, IL2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12(p70), IL-13, IL-15, IL-17, Eotaxin, Basic FGF, G-CSF, GM-CSF, IFN-[gamma], IP10, MCP-1, MIP-1[alpha], PDGF-BB, MIP-1[beta] RANTES, TNF-[beta], VEGF, IL-1[alpha], IL-2R[alpha], IL-3, IL-12(p40), IL-16, IL-18,
CTACK, GRO-[alpha], HGF, IFN-[alpha]2, LIF, MCP-3, M-CSF, MIF, MIG, [beta]-NGF, SCF, SCGF-[beta], SDF-1[alpha], TNF-[alpha], TRAIL) was performed on serum samples using a magnetic bead-based multiplex immunoassays (Bio-Plex) (BIO-RAD Laboratories, Milano, Italy) following manufactures' instructions.