CCL27

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CCL27

A gene on chromosome 9p13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL27 binds CCR10 and is chemotactic for skin-associated memory T cell; it is thought to play a role in mediating homing of lymphocytes to skin sites.
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(2001) CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin.
The molecular cues regulating immune cell trafficking
Other proinflammatory cytokines that were suppressed in the ZO-C heart included tumor necrosis factor a [31], CTACK (CCL27) [32], and the nursing hormone prolactin that is implicated in heart disease [33]; see Figure 4.
Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats
Deleuran, "TARC augments TNF-[alpha]-induced CTACK production in keratinocytes," Experimental Dermatology, vol.
Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors
TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis: effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines.
Microarray-based in vitro test system for the discrimination of contact allergens and irritants: identification of potential marker genes
The second ligand of CCR10 is CCL27 (also called cutaneous T cell-attracting chemokine or CTACK) [86] which is associated most commonly with the homing of T lymphocytes to the skin [87], but is indeed expressed by IECs.
Vicari et al., "CTACK, a skin-associated chemokine that preferentially attracts skinhoming memory T cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
Defensive Driving: Directing HIV-1 Vaccine-Induced Humoral Immunity to the Mucosa with Chemokine Adjuvants
In fact, a significant increase in the protein levels of cutaneous T-cell-attracting chemokine (CTACK), chemokine (C-X-C motif) ligand-16 (CXCL16), eotaxin-2, fractalkine, and Blymphocyte chemoattractant (BLC) was reported in the UCP2 gene-knockout mice [35].
Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
Luminex multiplex panel technology was used for simultaneous measurement of a panel of the following analytes: IL6, TNF-a, IL-5, Eotaxin, FGF-basic, PDGF-bb, VEGF, IP-10, CTACK, HGF, and SCGF-b.
Other markers, such as SMRP, pOPN, previously shown as diagnostic markers for MPM, and a panel of cytokines and grow factors (IL6, TNF-a, IL-5, Eotaxin, FGF-basic, PDGF-bb, VEGF, IP-10, CTACK, HGF, and SCGF-b) were studied.
A Novel Panel of Serum Biomarkers for MPM Diagnosis
The analysis of a 48 cytokines and chemokines panel (including IL-1[beta], IL-1ra, IL2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12(p70), IL-13, IL-15, IL-17, Eotaxin, Basic FGF, G-CSF, GM-CSF, IFN-[gamma], IP10, MCP-1, MIP-1[alpha], PDGF-BB, MIP-1[beta] RANTES, TNF-[beta], VEGF, IL-1[alpha], IL-2R[alpha], IL-3, IL-12(p40), IL-16, IL-18, CTACK, GRO-[alpha], HGF, IFN-[alpha]2, LIF, MCP-3, M-CSF, MIF, MIG, [beta]-NGF, SCF, SCGF-[beta], SDF-1[alpha], TNF-[alpha], TRAIL) was performed on serum samples using a magnetic bead-based multiplex immunoassays (Bio-Plex) (BIO-RAD Laboratories, Milano, Italy) following manufactures' instructions.
Cytokine levels in the serum of healthy subjects

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