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Demonstrated efficacy in a B7-H6-positive CT26 mouse colon cancer model, especially when administered in combination with a PD-1 inhibitor.
The average particle size of obtained honokiol micelle was about 40nm and was treated to CT26 murine colon carcinoma cells.
Here, in vitro data generated from HCT116-DUAL(TM) and in vivo data from CT26 tumors further demonstrate that NBTXR3 activated by radiotherapy is able to trigger a stronger activation of the cGAS-STING pathway, compared to radiotherapy alone, even in combination with the STING agonist 2',3'-cGAMP.
Accordingly, overexpression of TGF-[beta] in CT26 colorectal carcinoma cells enhanced tumor growth by suppressing antitumor T lymphocyte response in immune competent Balb/c mice .
In CT26 colorectal carcinoma-bearing mice, [[sup.18]F]FAZA PET uptake was increased in both tumor and muscle tissue in ketamine/xylazine-anesthetized animals as compared to isoflurane-anesthetized animals.
Meanwhile, depending on our fundamental research, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and crystal violet assay indicated that the ingredients of herbal extract medicines can inhibit 4T1 breast cancer and CT26 colon cell line growth (unpublished data).
Particles were injected intravenously into CT26 tumor-bearing mice and imaged using CT.
Jiang et al., "Effect of Salmonella treatment on an implanted tumor (CT26) in a mouse model," Journal of Microbiology, vol.
Nuciferine, an aporphine alkaloid, has been shown to reduce the viability of SY5Y human neuroblastoma cells and CT26 murine colon cancer cells and to inhibit tumor growth in nude mice xenografted with these cancer cell lines .
have reported that tumor destruction with combination therapy of intratumoral injected DCs and ATXS10Na(II)-PDT against CT26 tumors in BALB/c mice was greater than that of individual therapies .
In addition, MTS cell viability analysis revealed that AGAF treatment exerted no direct cytotoxic effects on the colon cancer cell line CT26 (data not show).
Ectopically expressing HCV-E2 envelope glycoprotein CT26 cell lines (E2-CT26 cells) and parental CT26 cells (mock cells) were established by G418 selection (9) (CT26 was purchased from The Culture Collection of Wuhan University), and cultured in RPMI 1640 medium with 10% (v/v) fetal bovine serum (Gibco/Invitrogen).
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