VCAN

(redirected from CSPG2)

VCAN

A gene on chromosome 5q14.3 that encodes an aggrecan/versican proteoglycan, which is a large chondroitin sulphate and major component of the extracellular matrix involved in cell adhesion, proliferation, migration and angiogenesis, and which plays a central role in tissue morphogenesis and maintenance.

Molecular pathology
VCAN mutations cause Wagner syndrome type 1.
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An earlier study (193) had reported that 4 genes that are affected by age-related methylation, ER, MYOD, CDKN2A exon 1, and CSPG2, are highly methylated in dysplastic colonic epithelium and that hypermethylation of 3 of these genes also occurred in the nondysplastic epithelium of patients with UC who had dysplasia or CRC elsewhere in their colon.