PTGDR2

(redirected from CRTH2)

PTGDR2

A gene on chromosome 11q12-q13.3 that encodes an orphan G protein-coupled receptor.
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References in periodicals archive ?
SLS-008: once-daily, oral CRTh2 (Chemo-attractant Receptor-homologous molecule expressed on Th2 cells) that focuses on an undisclosed pediatric orphan indication.
SLS-008: once-daily, oral CRTh2 that focuses on an undisclosed pediatric orphan indication.
Several biologies targeting different biomarkers such as anti-IL-4/IL-13 (dupilumab), (60,61) IL-17 (brodalumab and secukinumab [AIN457]), (62) tyrosine kinase KIT (imatinib), (63) thymic stromal lymphopoietin (TSLP; tezepelumab), (64) and CRTH2 (fevipiprant) (65) are in development.
In addition to KBP-5074, the company has several candidates in preclinical and early-stage clinical development, including KBP-7072, a 3G aminomethylcycline for multi-resistant bacterial infections, and KBP-7026, a novel CRTH2 receptor antagonist targeting asthma/COPD.
PGD2 stimulates ILC2 migration into the lung and drives the production of type 2 cytokines via its receptor CRTH2 [97] which is a distinctive marker of human ILC2s [31, 98].
Agrawal, QSAR Study of 2, 4-disubstituted Phenoxyacetic Acid Derivatives as a CRTh2 Receptor Antagonists, Chem.
Various antiasthma drugs targeting type 2 immune mediators, such as IL-4, IL-5, IL-13, TSLP, IL-33, and CRTH2, are now under development [5].
proposed another identification option for basophils for flow cytometry by gating cells with low side scattering which are prostaglandin DP2 receptor CRTH2 (CD294)-positive and CD3-negative [44].
ILC2s were analyzed according to the method reported by Mjosberg et al .[sup][16] Briefly, peripheral blood cells were stained simultaneously using an antihuman fluorescein isothiocyanate-conjugated lineage cocktail, phycoerythrin (PE)-conjugated CRTH2, and PE-CY7-conjugated CD127, or appropriate isotype controls (all from BD Pharmingen, San Diego, CA, USA).
The compound AP768 interacts with CRTH2, a novel target for asthma and allergic rhinitis.