CRIP2

CRIP2

A gene on chromosome 14q32.3 that encodes a cysteine-rich protein which is highly expressed during cardiovascular development. It bridges serum response factor and GATA proteins and stimulates smooth muscle target genes.
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ADAMTS9 CRIP2 ENGASE IL23A RT1-DA AHCY CTGF ERO1LB KRT20 S100A4 AMIGO3 DDIT3 ETV5 MANF SDF2L1 ANKRD37 DERL3 FGF18 MFSD2 SEC23B ATMIN DNAJB11 FOLR1 NR4A2 SEL1L BCAM DNAJB9 GGCT NUPR1 SLIT1 BET1 DNAJC3 GMPPB PDIA4 TM4SF1 CASP4 DUOX2 HSP90B1 PRIMA1 TMEM140 CDH1 DUSP5 HSPA5 PRSS8 TMEM66 COQ10B DYNLRB2 HYOU1 RIL ZFAND2A CRELD2 ELOVL2 IGF2BP2 RIOK3 Table 3: Target genes of the transcription factor PAX8 (gene symbol) [37].
Most of enriched category was Muscular System, in which 12 genes such as Myh6 (fold = -7.13), Myh7 (fold = 2.21), HSC70 (fold = -2.82), Tnni3 (fold = -4.85), Actc1 (fold = -2.06), Tpm2 (fold = 2.17), Tnnt1 (fold = 2.29), Tnni1 (fold = 2.38), Myom3 (fold = 4.25), Pln (fold = -2.83), Crip2 (fold = -2.32) and Csrp2 (fold = 2.47), were responsible for the functions of muscle development and contraction.