The activation mechanisms of other ER-resident transcription factors such as sterol regulatory element-binding protein (SREBP), activating transcription factor 6 (ATF6), OASIS, and cyclic AMP-responsive element-binding protein H (CREBH) have been closely studied to date.
(2006) Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.
During the preparation of this paper, a study published in Hepatology showed that the promoter of FSP27[beta] (the major isoform in the liver) was activated by the liver-enriched transcription factor cyclic AMP-responsive element-binding protein H (CREBH) .
Lee, "Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis," Hepatology, vol.
Pagliassotti, "Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin," Molecular and Cellular Biochemistry, vol.
An interesting link between ERRgamma transcriptional activity and metabolic inflammation has been established by the demonstration that overexpression of this receptor led to regulation of cAMP responsive element-binding protein H (CREBH), an endoplasmic reticulum-bound transcription factor that mediates endoplasmic reticulum stress by increasing expression of acute-phase proteins in response to inflammation.
Kim et al., "Orphan nuclear receptor err[gamma] induces C-reactive protein gene expression through induction of ER-bound bzip transmembrane transcription factor CREBH," PLoS ONE, vol.
Creb3l3, which is also known as CrebH, functions as an endoplasmic reticulum bound transcription factor responsible for regulating hepatic gluconeogenesis .
Yang et al., "Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH," Cell Metabolism, vol.