CREBBP


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Related to CREBBP: EP300

CREBBP

A gene on chromosome 16p13.3 that encodes a ubiquitously expressed protein involved in the transcriptional coactivation of various transcription factors. CREBBP acts as a scaffold to stabilise additional protein interactions with the transcription complex; it has intrinsic histone acetyltransferase activity, and acetylates both histone and non-histone proteins.

Molecular pathology
CREBBP mutations cause Rubinstein-Taybi syndrome (RTS); chromosomal translocations of CREBBP are associated with acute myeloid leukaemia.
References in periodicals archive ?
To evaluate the role of CREBBP on IFNT transcription, JEG-3 cells were cotransfected with the -654-IFNT-Luc construct along with Jun, Ets2, and/or Cdx2 expression plasmids, either with or without Oct4 or a CREBBP inhibitor, 12S E1A.
To determine whether either of these transcription factors directly interact with CREBBP, thereby resulting in changes in ovine IFNT gene transcription, co-immunoprecipitation studies were carried out.
This study represents the first to examine direct interactions between OCT4, CDX2, and CREBBP within the context of IFNT transcriptional regulation.
pombe); CHUK, conserved helix-loop-helix ubiquitous kinase; CREBBP, CREB binding protein (also known as CBP); CUL2, cullin 2; DAPK1, death-associated protein kinase 1; DAPK2, death-associated protein kinase 2; DAPK3, death-associated protein kinase 3; DGCR8, DiGeorge syndrome critical region gene 8; DROSHA, drosha, ribonuclease type III; E2F1, E2F transcription factor 1; EGF, epidermal growth factor; EGFL7, EGF-like-domain, multiple 7; EGFR, epidermal growth factor receptor; EGLN1, egl nine homolog 1 (C.