This inhibits its activity and attenuates protein translation while inducing the translation of activating transcription factor 4 (ATF4, also known as CREB2
) and other selected genes .
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Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change.
The antibodies used were Grp78 (76-E6), cAMP-responsive element (CRE) binding protein 2 CREB2
(also known as ATF4; C-20), and actin (I-19) (all from Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA); 94-kDa glucose-regulated protein (Grp94) and HSP70 (both from Stressgen Bioreagents, Victoria, British Columbia, Canada); and phosphorylated eIF2[alpha] (phospho-eIF2[alpha]; Ser51) and total eIF2[alpha] (both from Cell Signaling Technology, Inc., Beverly, MA, USA).