CREB1


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Related to CREB1: CREBBP, CREBP, KREB, CREB binding protein

CREB1

A gene on chromosome 2q34 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds as a homodimer to the cAMP-responsive element. CREB1 is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
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While other proteins (GSK3B, POU5F1, MAPK14, CREB1, SOX2, KLF4, PRKACA, MAPK10, STAT1, ACTB, TUBB3, MYC, GAPDH, AKT1, and CTNNB1) are related with process of aging, neuronal diseases, cardiovascular diseases, abnormal brain development, mental retardation, schizophrenia, and mycobacterial and viral infections [60-62].
Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders
Two polymorphisms were significantly associated with this response, but neither of the alleles lies in the coding area of the CREB1 gene.
Polymorphisms linked to risk of suicidality in men
CREB1 could be an important link to these cytokine activation pathways.
PCB 153 requires three steps to reach cyclin D1 (through PXR and CREB1); it requires the same intermediate steps to reach IL-8.
A systems biology approach reveals converging molecular mechanisms that link different POPs to common metabolic diseases
The CREB1 gene, located at 2q33.3, also encodes a member of the leucine zipper family.
Clear Cell Sarcoma-like Tumor of the Gastrointestinal Tract: An Evolving Entity
Carvajal-Gonzalez et al., "Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner," Journal of Molecular Biology, vol.
Aryl hydrocarbon receptor (AhR) modulates cockroach allergen-induced immune responses through active TGF[beta]1 release
One of the major transcription factors that recognizes the CRE is a protein called CRE-binding protein (CREB1), which functions as a transcriptional activator only after it is phosphorylated by either PKA, MAPK, or CamK.
CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation.
Molecular mechanisms of memory storage in Aplysia
Bellahcene, "CREB1 and AP-1 transcription factors JunD and Fra-2 regulate bone sialoprotein gene expression in human breast cancer cells," Bone, vol.
GosB Inhibits Triacylglycerol Synthesis and Promotes Cell Survival in Mouse Mammary Epithelial Cells
The second CRE/TRE site binds in vitro to CREB1 and the third site binds in vitro to ATF1/CREB1 [39].
Transcriptional and posttranscriptional regulations of the HLA-G gene
A team of Italian researchers at the Catholic University of Sacred Heart in Rome have discovered that this molecule, called CREB1, is triggered by 'caloric restriction' (low caloric diet) in the brain of mice.
Why eating less helps brain to stay young
A recent series described tumors with features similar to CCS-like gastrointestinal tumor as "malignant gastrointestinal neuroectodermal tumor." (15) These tumors of the GI tract share morphologic, immunohistochemical, and molecular similarities with our case, such as the presence of EWSR1 rearrangement in most cases, with 46% showing ATF1 and 22% showing CREB1 rearrangement.
Primary clear cell sarcoma of the tongue

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