While other proteins (GSK3B, POU5F1, MAPK14, CREB1
, SOX2, KLF4, PRKACA, MAPK10, STAT1, ACTB, TUBB3, MYC, GAPDH, AKT1, and CTNNB1) are related with process of aging, neuronal diseases, cardiovascular diseases, abnormal brain development, mental retardation, schizophrenia, and mycobacterial and viral infections [60-62].
Two polymorphisms were significantly associated with this response, but neither of the alleles lies in the coding area of the CREB1
CREB1 could be an important link to these cytokine activation pathways.
PCB 153 requires three steps to reach cyclin D1 (through PXR and CREB1); it requires the same intermediate steps to reach IL-8.
gene, located at 2q33.3, also encodes a member of the leucine zipper family.
Carvajal-Gonzalez et al., "Recruitment of CREB1
and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner," Journal of Molecular Biology, vol.
One of the major transcription factors that recognizes the CRE is a protein called CRE-binding protein (CREB1), which functions as a transcriptional activator only after it is phosphorylated by either PKA, MAPK, or CamK.
CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation.
and AP-1 transcription factors JunD and Fra-2 regulate bone sialoprotein gene expression in human breast cancer cells," Bone, vol.
The second CRE/TRE site binds in vitro to CREB1
and the third site binds in vitro to ATF1/CREB1 .
A team of Italian researchers at the Catholic University of Sacred Heart in Rome have discovered that this molecule, called CREB1
, is triggered by 'caloric restriction' (low caloric diet) in the brain of mice.
A recent series described tumors with features similar to CCS-like gastrointestinal tumor as "malignant gastrointestinal neuroectodermal tumor." (15) These tumors of the GI tract share morphologic, immunohistochemical, and molecular similarities with our case, such as the presence of EWSR1 rearrangement in most cases, with 46% showing ATF1 and 22% showing CREB1