CREB1

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CREB1

A gene on chromosome 2q34 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds as a homodimer to the cAMP-responsive element. CREB1 is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
References in periodicals archive ?
Kandel, "The molecular biology of memory: CAMP, PKA, CRE, CREB-1, CREB-2, and CPEB," Molecular Brain, vol.
CREB-1 alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation.
Thus, injection into the cell body of phosphorylated CREB-1 gives rise to LTF at all the synapses of the sensory neuron by seeding these synapses with the protein products of CRE-driven genes.
We determined levels of I[kappa]B[alpha] and phosphorylated ATF-2, c-Jun, and CREB-1 in control and ROFA-treated rabbit lungs by SDS-PAGE.
We used 20 [micro]g of nuclear protein extracts for the analyses of phosphorylated ATF-2, c-Jun, and CREB-1. Electrophoresed proteins were electro-blotted onto nitrocellulose (37).
Rabbit BDNF, rabbit p-CREB-1, rabbit CREB-1, rabbit [3-actin and secondary antibodies were purchased from Santa Cruz Biotechnology (USA).