CREBBP

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CREBBP

A gene on chromosome 16p13.3 that encodes a ubiquitously expressed protein involved in the transcriptional coactivation of various transcription factors. CREBBP acts as a scaffold to stabilise additional protein interactions with the transcription complex; it has intrinsic histone acetyltransferase activity, and acetylates both histone and non-histone proteins.

Molecular pathology
CREBBP mutations cause Rubinstein-Taybi syndrome (RTS); chromosomal translocations of CREBBP are associated with acute myeloid leukaemia.
References in periodicals archive ?
The activation of CREB is induced by phosphorylation within the CREB kinase inducible domain (KID) and recruitment of CBP (CREB binding protein)/p300.
Phosphorylated CREB, together with its coactivators, p300 and CBP (CREB Binding Protein) enhances the transcription of various genes by binding to specific DNA elements within gene promoter regions, referred to as CREs (cAMP-Response Elements).
(17) Interestingly, STAT3 and Smad1 form a complex bridged by a transcriptional coactivator, p300 or CREB binding protein (CBP), and synergistically induce astrocytic gene expression.
Neurotransmitters within the nervous system (such as ephedrine) travel through the G-protein-coupled receptors to activate the adenylate cyclase, to increase the intracellular cAMP levels, to activate the protein knases, and to make the CREB Ser-133 phosphorylates that binds specifically to the CREB binding protein (CBP).
Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation.
Alcohol exposure decreases CREB binding protein expression and histone acetylation in the developing cerebellum.
One candidate protein for this process is known as CBP, or CREB binding protein, which is central in the biochemistry of cellular survival.