Klozapin, norotrofin ailesi uyeleri olan BDNF, CREB
, NGF, sinapsin ve FGF2 gen ekspresyon seviyelerini fare hipokampusunda kontrol grubu ile karsilastirildiginda anlamli olarak artirdi.
The results obtained in the present study demonstrated that ip administration of VUF-8430 induces a decrease in CREB
and pCREB expression in the cerebellar vermis and prefrontal cortex of mice, suggesting that this dose impaired the activation of cell signaling pathways in these structures.
, a key protein that regulates gene transcription function, contains multiple activation sites that can be activated by a number of protein kinases including PKA, and it is one of the key nodes in the signaling transduction pathway of cAMP-PKA (Kasper et al., 2010).
Greenberg, "[Ca.sup.2+] influx regulates BDNF transcription by a CREB
family transcription factor-dependent mechanism," Neuron, vol.
Deletion in DCs Reduces Spontaneous B Cell Activation.
immunofluorescence was evident in NFL, GCL, and ONL in control rats (Figure 9(a), A-1).
Finally, inhibition of various kinases, PI3K/PKC/MEK/ERK, and their regulated transcription factor CREB
strongly inhibited LPA-induced DR6 expression.
In addition, EP4 siRNA and AH-23848 reversed Akt and CREB
phosphorylation and NF-[kappa]B inactivation, which are activated downstream signals of the EP4 pathway.
Immunofluorescence Analysis of CREB
. The mouse antimonkey CREB
polyclonal antibody was used as the primary antibody, the Alexa Fluor 488 goat anti-mouse fluorescent was used as the secondary antibody for indirect immunofluorescence labeling, and then DAPI staining solution was used for nuclear staining.
[sup], Both cAMP-dependent protein kinase A (PKA) and CREB
are activated in the course of spatial learning.
Increases in the phosphorylation of cycli cAMP response element binding protein (CREB
) and decreases in the content of calcineurin accompany thermal hyperalgesia following chronic constriction injury in rats.
The three transcription factors found to be most highly over-expressed in underfed, 38-day-old 6-arm plutei compared to their well-fed 13-day-old counterparts were CREB
, Elk, and FoxJ1 (Fig.