CREB1

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Related to CREB: CREB binding protein

CREB1

A gene on chromosome 2q34 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds as a homodimer to the cAMP-responsive element. CREB1 is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
References in periodicals archive ?
Klozapin, norotrofin ailesi uyeleri olan BDNF, CREB, NGF, sinapsin ve FGF2 gen ekspresyon seviyelerini fare hipokampusunda kontrol grubu ile karsilastirildiginda anlamli olarak artirdi.
The results obtained in the present study demonstrated that ip administration of VUF-8430 induces a decrease in CREB and pCREB expression in the cerebellar vermis and prefrontal cortex of mice, suggesting that this dose impaired the activation of cell signaling pathways in these structures.
CREB, a key protein that regulates gene transcription function, contains multiple activation sites that can be activated by a number of protein kinases including PKA, and it is one of the key nodes in the signaling transduction pathway of cAMP-PKA (Kasper et al., 2010).
Greenberg, "[Ca.sup.2+] influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism," Neuron, vol.
CREB immunofluorescence was evident in NFL, GCL, and ONL in control rats (Figure 9(a), A-1).
Finally, inhibition of various kinases, PI3K/PKC/MEK/ERK, and their regulated transcription factor CREB strongly inhibited LPA-induced DR6 expression.
In addition, EP4 siRNA and AH-23848 reversed Akt and CREB phosphorylation and NF-[kappa]B inactivation, which are activated downstream signals of the EP4 pathway.
Immunofluorescence Analysis of CREB. The mouse antimonkey CREB polyclonal antibody was used as the primary antibody, the Alexa Fluor 488 goat anti-mouse fluorescent was used as the secondary antibody for indirect immunofluorescence labeling, and then DAPI staining solution was used for nuclear staining.
[sup][25],[26] Both cAMP-dependent protein kinase A (PKA) and CREB are activated in the course of spatial learning.
Increases in the phosphorylation of cycli cAMP response element binding protein (CREB) and decreases in the content of calcineurin accompany thermal hyperalgesia following chronic constriction injury in rats.
The three transcription factors found to be most highly over-expressed in underfed, 38-day-old 6-arm plutei compared to their well-fed 13-day-old counterparts were CREB, Elk, and FoxJ1 (Fig.