clearance

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clear·ance

(klēr'ants),
1. Removal of a substance from the blood, for example, by renal excretion, expressed in terms of the volume flow of arterial blood or plasma that would contain the amount of substance removed per unit of time; measured in mL/min. Renal clearance of any substance except urea or free water is calculated as the urine flow in mL/min multiplied by the urinary concentration of the substance divided by the arterial plasma concentration of the substance; normal human values are commonly expressed per 1.73 m2 body surface area.
2. A condition in which bodies may pass each other without hindrance, or the distance between bodies.
3. Removal of something from some place; for example, esophageal acid clearance refers to removal from the esophagus of some acid that has refluxed into it from the stomach, evaluated by the time taken for restoration of a normal pH in the esophagus.

clearance

(klîr′əns)
n.
1. A space cleared; a clearing.
2.
a. The removal by the kidneys of a substance from blood plasma.
b. Renal clearance.
FDAspeak See Marketing clearance
Occupational medicine The amount of space above a worker’s head
Pharmacology A measure of the elimination of a drug, therapeutic agent, or other substance from the body or other biologic system; clearance is expressed as a hypothetical volume that is completely removed in a given unit of time
Pharmacokinetics The product of the volume of distribution and the elimination rate constant; much of a drug’s elimination is via the kidneys and clearance is commonly expressed in mL/min or L/hr
Physiology
(1) The removal of a substance from the blood by metabolism or excretion
(2) A quantitative measure of such a removal
Vox populi The amount of space between 2 closely related substances

clearance

Pharmacology The elimination of a drug, therapeutic agent, or other substance from the body or other biologic system; clearance is expressed as a hypothetical volume that is completely removed in a given unit of time; in terms of pharmacokinetics, clearance is the product of the volume of distribution and the elimination rate constant; much of a drug's elimination is via the kidneys and clearance is commonly expressed in mL/min or L/hr. See Hepatic clearance, Renal clearance, Therapeutic drug monitoring, Total body clearance Physiology
1. The removal of a substance from the blood by metabolism or excretion. See Nasal mucociliary clearance.
2. A quantitative measure of item 1.

clear·ance

(klēr'ăns)
1. Indicated as C with a subscript to show the substance removed: removal of a substance from the blood, e.g., by renal excretion, expressed in terms of the volume flow of arterial blood or plasma that would contain the amount of substance removed per unit time; measured in mL per minute; normal values in humans are commonly expressed per 1.73 m2 body surface area.
2. A condition in which bodies may pass each other without hindrance, or the distance between bodies.
3. Removal of something from some place; e.g., "esophageal acid clearance" refers to removal from the esophagus of acid that has refluxed into it from the stomach, evaluated by the time taken for restoration of a normal pH in the esophagus.

clearance

1. The removal of a substance from the blood, usually by the kidneys.
2. The rate of such removal.

clear·ance

(klēr'ăns)
Removal of something from an area.
References in periodicals archive ?
The manufacturer suggests that when treating an active duodenal ulcer, gastroesophageal reflux disease, and benign gastric ulcer, the dose for a patient with a CrCl 20 to 50 mL/minute should not exceed 150 mg in 24 hours, and for a patient with a CrCl of less than 20 mL/minute, the dose needs to be reduced to 150 mg every other day (Reliant Pharmaceuticals, Inc., 2005).
Our patient represented a case in which sCr and the CrCl did not accurately predict the serum amikacin predose concentration.
Crcl correlated better with CG eGFR than MDRD eGFR and there was also a very good correlation between CG eGFR and MDRD eGFR.
(35) CRCL, "Engagement with Key Communities Team," August 14, 2009.
Rivaroxaban use in a phase I study in subjects with moderate renal impairment (CrCl 30-49 mL/min) was associated with an increase in plasma concentration (area under the plasma concentration-time curve [AUC] increased 1.5-fold) [26].
(OTCBB: CRCL), a company with interests in a number of high-impact, large scale oil and gas plays in Texas, has named Thomas M Richards as its director, effective immediately.
However, it is recommended that the dose be adjusted for patients with renal insufficiency with a creatinine clearance (CrCl) of 10-30 ml/min.
Demographic, laboratory and clinical data were collected, including age, gender, body weight, white blood cell count, C-reactive protein, serum albumin, serum creatinine, Acute Physiology and Chronic Health Evaluation II scores at the time of intensive care unit (ICU) admission and initial vancomycin treatment, underlying diseases, microbiologic test results, vancomycin therapy data (date, dose and duration), creatinine clearance (CrCl) estimated by the Cockcroft-Gault formula at the time of vancomycin serum sampling, chest radiography findings, length of ICU stay, ventilation status and ICU discharge status.
The agency plans to sell the 200 posters online and donate the profits to the Coalition to Restore Coastal Louisiana (CRCL), a body set up to combat the damage caused by BP's oil slick.