Irinotecan (camptothecin-11 (CPT-11
)) is a topoisomerase I inhibitor that has been used in the treatment of a wide spectrum of cancer, particularly colorectal cancer.
 (2008) DTX [right arrow] PTX [right arrow] CPT-11
Tanizaki et al.
 Saitoh- CDDP, CPT-11
ANED, 12 Mo Sekiguchi et al.
A phase II study of CPT-11
, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer.
) is a camptothecin-derived cytotoxic anticancer drug.
Two clinically used CPT derivatives irinotecan (CPT-11
) and topotecan are widely used to inhibit the growth of lung cancer in combination with cisplatin, paclitaxel , and bevacizumab .
Initially, the collaboration will concentrate on the development of next-generation product candidate to TheraBiologics' TBX02, which uses an established NSC line engineered to express a modified carboxylesterase enzyme that converts the prodrug, CPT-11
(Irinotecan), to the potent chemotherapy agent, SN-38, which is 1000x more toxic to cancer cells than CPT-11
Establishment of a camptothecin analog (Cpt-11
)-resistant cell-line of human non-small cell lung-cancer--characterization and mechanism of resistance.
Including acetaminophen and the chemotherapy medication CPT-11
. The authors propose that the same mechanisms may be at work with environmental chemicals.
Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11
) and topotecan.
A retrospective study of bifractionated CPT-11
with LF5FU infusion (FOLFIRI-3) in colorectal cancer patients pretreated with oxaliplatin and CPT-11
Colorectal cancer patients were treated with oxaliplatin plus 5-fluorouracil (5-FU), or weekly CPT-11
or 5-FU and folates (FA).