CPT-11

An antineoplastic chemotherapeutic agent.

Farlex Partner Medical Dictionary © Farlex 2012

irinotecan

A topoisomerase-1 inhibitor and semisynthetic analogue of the natural alkaloid camptothecin, which is activated by hydrolysis in vivo to an active metabolit, SN-38, and inactivated by glucuronidation with uridine diphosphate glucoronosyltransferase 1A1 (UGT1A1). It was FDA-approved for managing colorectal carcinoma in 1994.

Adverse effects
Severe diarrhoea, possibly leading to dehydration, requiring aggressive antidiarrhoeal management with loperamide or Lomotil; immunosuppression with severe neutropaenia; functional overdose in patients who under-express UGT1A1 and cannot clear irinotecan as quickly (e.g., those with Gilbert syndrome as normal patients).

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References in periodicals archive ?

Irinotecan (camptothecin-11 (CPT-11)) is a topoisomerase I inhibitor that has been used in the treatment of a wide spectrum of cancer, particularly colorectal cancer.

The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer

[10] (2008) DTX [right arrow] PTX [right arrow] CPT-11 Tanizaki et al.

The Effectiveness of Hepatic Arterial Infusion Chemotherapy with 5-Fluorouracil/Cisplatin and Systemic Chemotherapy with Ramucirumab in Alpha-Fetoprotein-Producing Gastric Cancer with Multiple Liver Metastases

[7] Saitoh- CDDP, CPT-11 ANED, 12 Mo Sekiguchi et al.

The Cytoreductive Effect of Radiotherapy for Small Cell Ovarian Carcinoma of the Pulmonary Type: A Case Report and Review of the Literature

A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer.

The Inhibitory Effect of the Plant Alkaloid Camptothecin on the Rice Sheath Blight Pathogen Rhizoctonia solani

Irinotecan (CPT-11) is a camptothecin-derived cytotoxic anticancer drug.

Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats

Two clinically used CPT derivatives irinotecan (CPT-11) and topotecan are widely used to inhibit the growth of lung cancer in combination with cisplatin, paclitaxel [9], and bevacizumab [10].

An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation

Initially, the collaboration will concentrate on the development of next-generation product candidate to TheraBiologics' TBX02, which uses an established NSC line engineered to express a modified carboxylesterase enzyme that converts the prodrug, CPT-11 (Irinotecan), to the potent chemotherapy agent, SN-38, which is 1000x more toxic to cancer cells than CPT-11.

GenVec signs collaboration agreement with TheraBiologics

Establishment of a camptothecin analog (Cpt-11)-resistant cell-line of human non-small cell lung-cancer--characterization and mechanism of resistance.

Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells

Including acetaminophen and the chemotherapy medication CPT-11. The authors propose that the same mechanisms may be at work with environmental chemicals.

Gut check: do interactions between environmental chemicals and intestinal microbiota affect obesity and diabetes?

Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan.

Camptothecins and their novel anticancer properties evaluated by using pass method

A retrospective study of bifractionated CPT-11 with LF5FU infusion (FOLFIRI-3) in colorectal cancer patients pretreated with oxaliplatin and CPT-11 containing chemotherapies

Colorectal cancer patients were treated with oxaliplatin plus 5-fluorouracil (5-FU), or weekly CPT-11 or 5-FU and folates (FA).

Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms