CYP3A4

(redirected from CP34)

CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
References in classic literature ?
Then, having said everything that could stir a man's spleen or pique his valor, they would dare their imaginary hearers, now that the Bannacks were few in number, to come and take their revenge--receiving no reply to this valorous bravado, they would conclude by all kinds of sneers and insults, deriding the Blackfeet for dastards and poltroons, that dared not accept their challenge.
She is not a woman to be flattered because I made myself despicable-- to believe that I must be true to her because I was a dastard to you.
Oh, dastard hand," Peter said, and he raised the arrow to use it as a dagger.
Liar and scoundrel you are, in every action of your life; theft is your trade; and double dastard you must be, or you were not here today.
Since, if base fear his dastard step withdraws, From death he cannot fly:--One common grave Receives, at last, the coward and the brave.
On one theme, which is commonly before our eyes, and in respect of which our national character is changing fast, let the plain Truth be spoken, and let us not, like dastards, beat about the bush by hinting at the Spaniard and the fierce Italian.
And now, my friends - my labouring friends, for I rejoice and triumph in that stigma - my friends whose hard but honest beds are made in toil, and whose scanty but independent pots are boiled in hardship; and now, I say, my friends, what appellation has that dastard craven taken to himself, when, with the mask torn from his features, he stands before us in all his native deformity, a What?
For, he was quite as much of a dastard as the other, and had been in equal danger of falling into the second place for good, when he took heart just in time, to act upon the information conveyed to him by Fledgeby's eye.
Yes, you pitiful dastard,' retorted the lovely damsel, 'I understand you.
This project involves work installing PTC Radio Cases on foundations or elevated platforms, Digital Subscriber Line (DSL) Cases, cabling, PTC antennas and poles on All MNR territory including the Park Ave Tunnel EXCEPT the Waterbury branch, CP26 thru CP34, and from CP255 thru CP274.
For civilians, this is defined as either any Department of the Army civilian employee who has been employed within the CP34 career field or a civilian from any civilian career field who has worked for a Signal Organization for over ten years.