CYP3A4

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CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Members of the band are David McEathron, CP33, vocals; Berget Borowitz on drums, vocals; Drake Martin on bass; Jillian Meredith on
Its primary competitors include the Beretta U22 Neos ($325); the new Kel-Tec CP33 ($475); the hammer-fired Ruger SR22 ($440); the Smith & Wesson M&P22 ($419) and M&P22 Compact ($390); and Walther's P22 ($320).
So, it was great--but not totally unexpected--when Kel-Tec unveiled their latest product at SHOT Show 2019: the CP33.
Chambered in .221r, the CP33 distinguishes itself through its capacity--a whopping 33 rounds in a single, flush-fitting magazine!
Chambered in .22 LR, Kel-Tec's CP33 pistol is both optic- and suppressor-ready.
Member/ [[delta].sup.13]C [[delta].sup.18]O Sample No ([per thousand] VPDB) ([per thousand] VPDB) Mesa Quemada CP47 -4.1 -11.5 CP46 1.4 -13.3 CP45 2.2 -12.7 Cerro La Espina CP43 -0.1 -9.6 CP42 1.4 -10.0 CP41 0.4 -9.5 CP40 1.4 -10.6 CP38 0.6 -10.5 CP36 1.2 -11.1 CP35 2.2 -11.3 CP33 1.8 -13.0 Los Coyotes CP29 0.6 -10.1 CP28 1.3 -9.5 CP26 1.5 -9.9 CP25 -1.5 -9.4 CP24 -0.9 -9.3 CP22 -2.5 -8.9 CP20 -2.3 -9.4 CP18 -0.3 -9.3 CP17 1.2 -10.8 CP15 -1.6 -9.7 CP14 -1.5 -9.3 Tuape Shale CP12 -0.4 -10.0 CP10 -1.1 -11.9 CP9 -2.4 -10.2 CP6 0.0 -11.3 Cerro La Ceja CP4 1.3 -11.2 CP3 0.2 -9.9 CP1 -2.1 -13.4 Table 2.-Mn, Sr and strontium isotope values for limestones of Mural Formation.
For example, Conservation Practice 33 (CP33)--Habitat Buffers for Upland Birds was created to ameliorate declines of northern bobwhite (Colinus virginianus) and other grassland birds (Burger et al., 2006).
CRP grasslands (like CP33 Habitat Buffers) must be disturbed periodically during the contract period (i.e., mid-contract management) to promote habitat diversity and maintain early successional herbaceous habitat required by many grassland birds (Hamrick et al., 2006; Negus et al., 2010), and this is required in some contracts.
To provide information about how fire ants respond to mid-contract management, we measured fire ant mound density and foraging activity in prescribed burned, disked and undisturbed controls in CP33 native grass buffers in northeastern Mississippi.
CP33 is also still adding some habitat in the Delta."--Steven Fowler, quail program coordinator
42) Foroon we oiss feawum wordum saedon, oy we woldongecyoan hu micel sio byroen bio oaes lareowdomes, oylces aenig hine underfon durre oara oe his unwieroe sie; CP33.9