COX-2 inhibitor


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COX-2 inhibitor

A drug class that relieves inflammation and pain by inhibiting the action of cyclooxygenase-2.

Prostanoids that mediate inflammation, pain, and fever are synthesized through the action of cyclooxygenase-2 (COX-2), an enzyme that is constitutively expressed in the brain but can be induced in other tissues by cytokines. In both osteoarthritis and rheumatoid arthritis, COX-2 inhibitors have been shown to be superior in pain relief to acetaminophen and placebo, and equivalent to nonselective nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen and naproxen. In rheumatoid arthritis, COX-2 inhibitors are not disease-modifying drugs. Because nonselective NSAIDs inhibit not only COX-2 but also inhibit COX-1, which plays a role in platelet aggregation and gastric mucosal protection, their use is associated with a higher risk of gastrointestinal bleeding than that of selective COX-2 inhibitors. Like NSAIDs, however, the selective agents can cause liver and kidney toxicity, fluid retention, and hypertension. One of them (rofecoxib) was withdrawn by the manufacturer after 5 years on the market because of an unacceptably high incidence of heart attack and thrombotic stroke in patients receiving it for 18 months or more. For these reasons and because they are more expensive than NSAIDs, COX-2 inhibitors are indicated chiefly in patients who are at increased risk of gastrointestinal bleeding.

COX-2 inhibitor

n.
Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.

COX-2 inhibitor

Cyclooxygenase-2 inhibitor Pain management A class of analgesics with fewer side effects than those of conventional NSAIDs–which inhibit both cyclooxygenases–COX-1 and COX-2; COX-1 protects the gastric mucosa, preventing ulcers, bleeding, and other digestive tract problems. See COX-2, Prostaglandin.

COX-2 in·hib·i·tor

(in-hibi-tŏr)
A drug class that relieves inflammation and pain by inhibiting the action of cyclooxygenase-2.
References in periodicals archive ?
More information on the raw delay measures is presented in Table 2, which shows the average delay time between the diagnosis and the first long-term use of each COX-2 inhibitor as well as the number of people who ultimately adopt each.
Expenditures and number of prescription claims were analyzed for recipients who were (1) taking a COX-2 inhibitor in the 12 months before the PAR program; (2) switched to an NSAID, a salicylate, or other pain relievers because of the PAR program; and (3) remained on an NSAID or other pain relievers for the 12 months following implementation of the PAR.
Cannon said he believed that all COX-2 inhibitors increased that risk.
The FDA's decision is stunning because it went against the vote of the drug safety advisory committee, which decided in February to allow the continued marketing of COX-2 inhibitors, including Celebrex (celecoxib) and Bextra.
Leiner Health Products says that it supplies naproxen (the generic equivalent of Aleve) and store brand ibuprofen (the generic equivalent to Advil and Motrin) to many mass market retailers and that the products offer considerable savings when compared with COX-2 inhibitors. For example, a Leiner 100-count bottle of 220-mg naproxen retails for about 6 cents per pill, or $6 per bottle.
In addition, "Vioxx is the only selective COX-2 inhibitor currently available in liquid form and is easily taken by young children," Dr.
An injectable form of acetaminophen (the active ingredient in Tylenol) and a member of a new class of drugs called COX-2 inhibitors hold promise as safe and effective tools for controlling surgical pain, according to the American Society of Anesthesiologists.
I'm also watching this aspect of the COX-2 inhibitor story very closely.
Meloxicam is a cox-2 inhibitor recently approved for treating OA.
How health plans react to the launch of cox-2 inhibitors may serve as an example for future pharmacy management efforts.
Furthermore, chiropractic and acupuncture were added for reduction of pain and compared to traditional and COX-2 inhibitor NSAIDS after three months of chiropractic and acupuncture treatment.