COX-2 inhibitor

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COX-2 inhibitor

A drug class that relieves inflammation and pain by inhibiting the action of cyclooxygenase-2.

Prostanoids that mediate inflammation, pain, and fever are synthesized through the action of cyclooxygenase-2 (COX-2), an enzyme that is constitutively expressed in the brain but can be induced in other tissues by cytokines. In both osteoarthritis and rheumatoid arthritis, COX-2 inhibitors have been shown to be superior in pain relief to acetaminophen and placebo, and equivalent to nonselective nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen and naproxen. In rheumatoid arthritis, COX-2 inhibitors are not disease-modifying drugs. Because nonselective NSAIDs inhibit not only COX-2 but also inhibit COX-1, which plays a role in platelet aggregation and gastric mucosal protection, their use is associated with a higher risk of gastrointestinal bleeding than that of selective COX-2 inhibitors. Like NSAIDs, however, the selective agents can cause liver and kidney toxicity, fluid retention, and hypertension. One of them (rofecoxib) was withdrawn by the manufacturer after 5 years on the market because of an unacceptably high incidence of heart attack and thrombotic stroke in patients receiving it for 18 months or more. For these reasons and because they are more expensive than NSAIDs, COX-2 inhibitors are indicated chiefly in patients who are at increased risk of gastrointestinal bleeding.

COX-2 inhibitor

n.
Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.

COX-2 inhibitor

Cyclooxygenase-2 inhibitor Pain management A class of analgesics with fewer side effects than those of conventional NSAIDs–which inhibit both cyclooxygenases–COX-1 and COX-2; COX-1 protects the gastric mucosa, preventing ulcers, bleeding, and other digestive tract problems. See COX-2, Prostaglandin.

COX-2 in·hib·i·tor

(in-hibi-tŏr)
A drug class that relieves inflammation and pain by inhibiting the action of cyclooxygenase-2.
References in periodicals archive ?
Initially, we determined the function of COX-2 inhibition using virtual screening for prediction in silico and purified human COX-2 activity assay for further validation in vitro.
COX-2 inhibition by COX-2 inhibitors and NSAIDs results in a disturbance in the equilibrium of COX-1 and COX-2, which predisposes to a prothrombotic state and increased cardiovascular events.
We were pleased that the results from our clinical trial largely confirmed the existing data from several pre-clinical studies by showing that COX-2 inhibition leads to changes in cell proliferation, apoptosis, and extracellular matrix biology in primary breast cancer tissues," added Veeck.
Horphag Research, the exclusive worldwide distributor of Pycnogenol(R) has filed for several patents for Pycnogenol's(R) application for COX-1 and COX-2 inhibition and treatment of osteoarthritis.
Brunswick Laboratories has completed the development of its assays for COX-1 and COX-2 inhibition.
Maqui Superberry is an antioxidant supplement for healthy aging, inhibiting free radicals, strengthening the immune system and to support COX-2 inhibition.
Previous studies have shown that COX-2 inhibition by selective COX-2 inhibitors or small interfering RNA (siRNA) suppresses cell proliferation and induces apoptosis in human gastric cancer cells (Sun et al.
The FlexProtex(TM) formula works on the same mechanism of COX-2 inhibition that many of the pharmaceutical drugs do to help in the management of flexibility, joint health and arthritis, a crippling and debilitating disease.
DrD: I did the in vitro COX-2 inhibition assays with a colleague I worked with at the NIH, who has done thousands of these assays
Hoon noted that COX-2 remains a significant research interest for all gastrointestinal cancers, and that previous studies have suggested COX-2 inhibition can play a role in colon cancer prevention.
Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events.