NR2F2

(redirected from COUP-TFII)

NR2F2

A gene on chromosome 15q26 that encodes a member of the steroid thyroid hormone superfamily of nuclear receptors, which is a ligand-activated transcription factor involved in regulating a wide range of genes.
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Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells.
Important representatives of this group are CREB, nuclear receptors (such as LXR, RAR/ RXR, VDR, COUP-TFII, and PPARgamma), STATs, and NFkappaB [6-12].
Furthermore, COUP-TFII was found to be necessary for the function of the renin gene proximal promoter CRE [15].