CARD16

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CARD16

A gene on chromosome 11q22.3 that encodes a protein which downregulates procaspase-1/CASP1 activation by inhibiting the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release in response to lipopolysaccharides during inflammation. CARD 16 induces NF-kappa-B activation during the pro-inflammatory cytokine response; it inhibits CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death (but not ER stress-mediated cell death). It blocks CASP1 and CASP4 activation, possibly by preventing the interaction between CASP1 and RIPK2.

Molecular pathology
CARD16 is downregulated in patients with clinical Huntington’s disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
This is based on Fitch's expectation that the company will maintain an adjusted debt level of approximately COP4 trillion and generate an average EBITDA of approximately COP1.45 trillion during 2018-2021.
Global Banking News-July 9, 2018-Ecopetrol SA to prepay COP1.4tn entire syndicated loan
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The 94 amino acids long at COP1 protein were predicted to have a molecular weight of 10185.87 Da and an isoelectric point (pI) of 3.84.
In an open letter to President Duterte, some 100 environmental, health and labor rights advocates belonging to the EcoWaste Coalition pressed the government to work for the immediate ratification of the historic global agreement, and to secure the required concurrence of the Senate before the first Conference of Parties (COP1) scheduled on Sept.
[18] revealed that UV-B radiation stimulated COP1 and UVR8 photoperception protein, enhancing accumulation of anti-ultraviolet molecules.
Software Sales: COP1.24trn in 2016 to COP1.74trn by 2020, at a CAGR of 8.7%.
1995 BERLIN (COP1) First Conference of the Parties (COP) annual meeting to assess progress in dealing with climate change
The report and analysis compiled by the UN Office for Disaster Risk Reduction (UNISDR) and the Belgian-based Centre for Research on the Epidemiology of Disasters (CRED) demonstrates that since the first Climate Change Conference (COP1) in 1995, 606,000 lives have been lost and 4.1 billion people have been injured, left homeless or in need of emergency assistance as a result of weather-related disasters.
Software Sales: COP1.16trn in 2014 to COP1.84trn by 2019.