CARD16

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CARD16

A gene on chromosome 11q22.3 that encodes a protein which downregulates procaspase-1/CASP1 activation by inhibiting the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release in response to lipopolysaccharides during inflammation. CARD 16 induces NF-kappa-B activation during the pro-inflammatory cytokine response; it inhibits CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death (but not ER stress-mediated cell death). It blocks CASP1 and CASP4 activation, possibly by preventing the interaction between CASP1 and RIPK2.

Molecular pathology
CARD16 is downregulated in patients with clinical Huntington’s disease.
References in periodicals archive ?
Hewlett High School in Hewlett, New York, will share the $100,000 Grand Prize in the Team category for investigating COP1, a key protein in plants and animals.
Although many proteins have been found to interact with cryptochromes, for example, interact with COP1 in mediating the rhythms of flowering in plants, the receptors of cryptochrome underlying the magnetoreception are still unknown.
The purpose is to draw the world's attention to climate degradation, ahead of the COP1 5.
Microarray analysis found three genes were upregulated only in the depressed patients: YBX1, COP1, and FKSG2.
A: GET hold of the Inland Revenue's leaflet COP1 "Putting Things Right: How To Complain.
Its reference number is COP1 and it's available on the net at www.
Rising Tide draws its roots from the European youth NGO scene, who have carried out sporadic Europe-based attacks on international climate negotiations (at COP1 in Berlin in 1995, protesters refused to let the negotiators leave the building until they had made a real commitment to protecting the climate).
While COP1 did not move nearly as far as the WCC and many others had hoped, it did agree to begin negotiations on a more specific treaty for industrialized countries to limit their emissions.
Named COP1, the protein is likely among the first in line to receive commands from phytochrome.
Medical devices: COP1,667bn (US$880mn) in 2010 to COP1,860bn (US$1.
In their project,COP1 Arrests Photomorphogenesis in Dark Grown Gametophytes of Ceratopteris richardii; A Study of COP1 in Cryptogams, the team established a new model system to research COP-1.