CARD16

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CARD16

A gene on chromosome 11q22.3 that encodes a protein which downregulates procaspase-1/CASP1 activation by inhibiting the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release in response to lipopolysaccharides during inflammation. CARD 16 induces NF-kappa-B activation during the pro-inflammatory cytokine response; it inhibits CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death (but not ER stress-mediated cell death). It blocks CASP1 and CASP4 activation, possibly by preventing the interaction between CASP1 and RIPK2.

Molecular pathology
CARD16 is downregulated in patients with clinical Huntington’s disease.
References in periodicals archive ?
By ratifying the Convention, the Philippines can attend the COP1 not as a mere observer but as a full participant, and can then build on its progressive policies and programs.
In 2012 it had a net profit of over 500,000 billion COP1 Regarding ownership of Avianca's shares, there are two main shareholders: Synergy Aerospace Corp (58.
The target, which includes Seguros Colpatria SA, Seguros de Vida Colpatria SA, Capitalizadora Colpatria SA and Colpatria Medicina Prepagada SA, posted revenues of COP1.
En este grupo se encuentran proteinas celulares como COP1 (CARD-only protein 1), Iceberg, INCA (inhibitory CARD) y caspasa-12, las cuales poseen dominios CARD; y las proteinas de la familia POP (PYD only proteins), las cuales poseen dominios PYD (79-82).
Although many proteins have been found to interact with cryptochromes, for example, interact with COP1 in mediating the rhythms of flowering in plants, the receptors of cryptochrome underlying the magnetoreception are still unknown.
The purpose is to draw the world's attention to climate degradation, ahead of the COP1 5.
Microarray analysis found three genes were upregulated only in the depressed patients: YBX1, COP1, and FKSG2.
La degradacion depende de la interaccion con las enzimas ubiquitin E3 ligasas hdm-2 (homologo humano de murine double minute 2 o mdm2]), pirh2 (proteina inducida por p53, con un dominio dedos de zinc llamado RING-H2), COP1 (fotomorfogenico 1 constitutivo) y ARFBP17HectH9 con las que forma complejos estables, lo que bloquea su accion como factor de transcripcion, pues impide su union con las secuencias blanco de ADN y ademas favorece su ubiquitinacion y posterior proteolisis (44-46).
La COP1, establecio en 1995 un programa piloto llamado AIC, bajo el cual, los proyectos de reduccion y captura de GEI pueden ser llevados a cabo a traves de asociaciones entre un inversionista de un pais desarrollado y un hospedero de un pais en desarrollo o con economia en transicion.
A: GET hold of the Inland Revenue's leaflet COP1 "Putting Things Right: How To Complain.