COMT inhibitors

COMT inhibitors

Drugs that block catechol-o-methyl transferase, an enzyme that breaks down dopamine. COMT inhibitors include entacapone and tolcapone.
Mentioned in: Parkinson Disease
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Based on drug class, the market has been further segmented into Levodopa combination, dopamine agonists, MAO-B Inhibitors, COMT Inhibitors, and others.
Both were clinical trials with COMT inhibitors. One of them [19] used WOQ-9 and reported improvement in most items in proportion of patients with improvements; however, it did not provide data to calculate the effect size.
* Catechol-O-methyltransferase inhibitors (COMT inhibitors) These are prescribed for people in later stages of Parkinson's disease.
COMT inhibitors may boost levodopa/carbidopa's effects
Evidence indicates adding COMT inhibitors to levodopa therapy can reduce the end-of-dose failure patients experience as the effect of levodopa decreases, and also decrease the motor fluctuations (Chan et al., 2008; Damier, Viallet, Ziegler, Bourdeix, & Rerat, 2008).
The claim that this may prevent later motor complications needs to be further substantiated, but there may be a role for early introduction of COMT inhibitors with levodopa.
On the other hand, we found no significant role of COMT inhibitors in sparing SAM or lowering tHcy in L-dopatreated patients.
The COMT inhibitors tolcapone and entacapone are other new additions.
They believe that one way could be to offer targeted therapies with drugs like COMT inhibitors to carriers of the gene.