COMT


Also found in: Acronyms.

COMT

Catechol-O-methyltransferase, an enzyme that breaks down dopamine and l-dopa in the brain and thus reduces the effectiveness of some treatments for Parkinson's disease. Drugs that inhibit COMT improve patient responsiveness to treatment with levodopa, one of the mainstays of treatment for Parkinson's disease.
References in periodicals archive ?
Catechol-O-methyltransferase (COMT) is an enzyme which involved in metabolizing many catecholamine neurotransmitters, including dopamine and epinephrine (Grossman et al., 1992).
CoMT is similar to Community Music in that it is also a participatory intervention wherein everyone is equal; and it is participant and not expert led.
Nonetheless they noted that given that aspirin was preventively prescribed to millions of individuals and the COMT genetic variant was extremely common, this study underscores the potential importance of individualizing therapies based on genetic profiles.
Binary logistic regression was used in assessing the correlation between COMT genotype and pain among PD patients, as well as in analyzing PD-related pain, and covariates were age, sex, onset age, duration of disease, duration of L-Dopa medication, and UPDRS.
Various studies have found evidence indicating that polymorphism in both the 5-HTT gene and the COMT gene are linked with differences in the Big Five Personality traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism and Openness).
Existen estudios que sugieren que el alelo que codifica un COMT de actividad baja (COMT-L) puede ser un marcador susceptible para RCIU (6).
She added: "This is the first study to show that the combined effects of the COMT gene with adolescent cannabis use cause physical changes in the brain regions associated with schizophrenia."
The next morning we visited a bigger dairy - or a 'fruitiere' as it's called, because milk and therefore cheese, is considered a fruit or product of the earth - to see how the enormous wheels of Comt are produced, then routinely rubbed in salt during the ageing process.
A variety of different studies of the effect of the low- and high-activity COMT alleles have shown that the biologic context in which each allele operates determines its ultimate effects on cognition and the risk of schizophrenia.
He also hypothesizes that a dopamine drought in children who inherit a single copy of the strong COMT variant can also foster psychotic symptoms.--B.B.
Researchers in the US discovered the strong link between COMT and anxiety while investigating the roots of alcoholism.