PLAG1(redirected from COL1A2/PLAG1 fusion)
PLAG1A gene on chromosome 8q12 that encodes PLAG1, a zinc finger transcription factor that is consistently rearranged in pleomorphic adenomas of the salivary gland. PLAG1 activation results in upregulation of IGFII, leading to uncontrolled cell proliferation in cultured cells; other genes upregulated by PLAG1 include CRLF1, CRABP2, CRIP2 and PIGF.
PLAG1 overexpression occurs in pleomorphic adenomas of the salivary gland, lipoblastoma and hepatoblastoma, and co-operates with CBFB-MYH11, a fusion gene in myeloid leukaemia.
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