CNS leukemia

CNS leukemia

Central nervous system leukemia, see there.
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ALL patients with the initial WBC<100 x109/L, patients of T-ALL with WBC<50 x109 /L, patients with Ph+ ALL and patients with CNS leukemia at diagnosis were received craniospinal radiotherapy
Bone Loss in Pediatric Survivors of Acute Lymphoblastic Leukemia
Extramedullary diseases such as hepatomegaly, splenomegaly, and lymphadenopathy are seen less commonly in APL compared with other subtypes of AML, and CNS leukemia is rare [1, 9].
Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate
In March 2014, an analysis of cerebrospinal fluid (CSF) showed increased protein content (0.49 g/L), megakaryocyte number (10.0 x 10[sup]6/L), and 3% myeloblasts despite repeated intrathecal injections for prophylaxis of CNS leukemia. MRI of the head revealed no leukemia infiltration, and the BM remained in complete remission.
Paraplegia as Manifestation of an Isolated Central Nervous System Relapse Following Allogeneic Hematopoietic Stem Cell Transplantation in a Woman with Acute Myelogenous Leukemia
CT abnormallities and altered methotrexate clearence in children with CNS leukemia. Neurology 1984;34:229-33.
The impact of low dose methotrexate on cerebral complications in acute lymphoblastic leukemia treatment/Akut lenfoblastik losemi tedavisinde dussuk dozda metotreksatin beyin komplikasyonlarina etkisi
Before the introduction of treatment for occult CNS leukemia, up to 75% of children with ALL had CNS-related relapses.
Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited
"So far in humans, it appears that only CML cases that progress to lymphoid blast crisis (a marked increase in immature cells) or patients with Philadelphia chromosome-positive ALL are at risk for CNS leukemia," he said.
Leukemia treatment ineffective in rare cases

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