ALL patients with the initial WBC<100 x109/L, patients of T-ALL with WBC<50 x109 /L, patients with Ph+ ALL and patients with CNS leukemia
at diagnosis were received craniospinal radiotherapy
Extramedullary diseases such as hepatomegaly, splenomegaly, and lymphadenopathy are seen less commonly in APL compared with other subtypes of AML, and CNS leukemia
is rare [1, 9].
In March 2014, an analysis of cerebrospinal fluid (CSF) showed increased protein content (0.49 g/L), megakaryocyte number (10.0 x 10[sup]6/L), and 3% myeloblasts despite repeated intrathecal injections for prophylaxis of CNS leukemia
. MRI of the head revealed no leukemia infiltration, and the BM remained in complete remission.
CT abnormallities and altered methotrexate clearence in children with CNS leukemia
. Neurology 1984;34:229-33.
Before the introduction of treatment for occult CNS leukemia
, up to 75% of children with ALL had CNS-related relapses.
"So far in humans, it appears that only CML cases that progress to lymphoid blast crisis (a marked increase in immature cells) or patients with Philadelphia chromosome-positive ALL are at risk for CNS leukemia
," he said.