CNR2

CNR2

A gene on chromosome 1p36.11 that encodes one of two cannabinoid receptors, which belong to the G protein-coupled receptor family. CNR2 inhibits adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner, and is responsible for cannabinoid-induced CNS effects (e.g., effects on mood and cognition) of marijuana. CNR2 may play a role in the inflammatory response, nociceptive transmission and in bone homeostasis. CNR2 is also a less preferred gene symbol for what is now designated as PCDHA6, see there.
References in periodicals archive ?
CB2 is codified by gene CNR2, which is located in the chromosome lp36.
Saikosaponin C (SSc), a major component of Bupleuri Radix, interacted with CNR2. Activation of CNR2 inhibits the release of lymphokine and angiogenic factors, thus influencing the inflammation process and carcinogenesis [39].
Meanwhile, the average donations obtained under the CNR treatments were 104.61 points (CNR1), 97.26 points (CNR2), 113.11 points (CNR3), and 86.45 points (CNRA), respectively.
Similarly, 85 points became a focal donation point in CNR2, and 120 points became a focal donation point in CNR3.
Two single nucleotide polymorphisms of rs4237 and rs2501431 in CNR2 (Cannabinoid Receptor 2) gene may result in postmenopausal osteoporosis in Han Chinese women [11].
Li, "Evaluation of common variants in CNR2 gene for bone mineral density and osteoporosis susceptibility in postmenopausal women of Han Chinese," Osteoporosis International, vol.
Cannabinoids may control the growth of human cancers, in part, through the cannabinoid receptor 2 gene (CNR2), which emerged as the best-connected "super hub" in an inferred large-scale association network for breast cancer data (Schafer & Strimmer 2005).