PRKAR1A

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PRKAR1A

A gene on chromosome 17q23-q24 that encodes one of the regulatory subunits that comprise cAMP-dependent protein kinase. This enzyme transduces activating signals by phosphorylating different target proteins. PRKAR1A downregulates expression of liver genes in hepatoma/fibroblast hybrids.

Molecular pathology
PRKAR1A mutations cause Carney complex; it can fuse to the RET proto-oncogene by gene rearrangement and form PTC2, a  thyroid tumour-specific chimeric oncogene.
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References in periodicals archive ?
[4] MIM Number: 160980, Carney Complex, Type 1; CNC1, Online Mendelian Inheritance in Man (OMIM), Johns
Primary pigmented adrenocortical nodular disease (PPNAD; MIM 610489) is a dominantly inherited genetic disorder with the majority of cases associated with Carney Complex type 1 (CNC1; MIM 160980).
Technologies include complete manufacturing facilities with EDM, Wire EDM, and CNC1 machining.