Cytomegalovirus

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Cytomegalovirus

 [si″to-meg´ah-lo-vi″rus]
a genus of herpesviruses closely related to genus Roseolovirus, containing the single species human herpesvirus 5. It is transmitted by multiple routes and causes infection that is usually mild or subclinical but may be symptomatic (cytomegalic inclusion disease).

cytomegalovirus

 (CMV) [si″to-meg´ah-lo-vi″rus]
any of a subfamily of host-specific herpesviruses infecting humans, monkeys, and rodents, producing unique large cells with inclusion bodies. Opportunistic infection with this virus is common in immunocompromised individuals, causing clinical illnesses such as cytomegalovirus retinitis, pneumonia, esophagitis, colitis, adrenalitis, and hepatitis. It can also cause cytomegalic inclusion disease, a variety of gastrointestinal infections, and encephalitis. Most infections are mild in immunocompetent persons, but it has been associated with a syndrome called cytomegalovirus mononucleosis.
cytomegalovirus disease cytomegalic inclusion disease.

Cy·to·meg·a·lo·vi·rus (CMV),

(sī'tō-meg'ă-lō-vī'rŭs),
A group of viruses in the family Herpesviridae infecting humans and other animals, many of these viruses having special affinity for salivary glands, and causing enlargement of cells of various organs and development of characteristic inclusions (owl eye) in the cytoplasm or nucleus. Infection of embryo in utero may result in malformation and fetal death. They are all species specific and include salivary virus, inclusion body rhinitis virus of pigs, and others.
[cyto- + G. megas, big]

cytomegalovirus

(sī′tə-mĕg′ə-lō-vī′rəs)
n. Abbr. CMV
Any of a group of herpesviruses that attack and enlarge epithelial cells. Such viruses also cause a disease of infants characterized by circulatory dysfunction and microcephaly.

cytomegalovirus

A globally distributed herpesvirus (HHV-3) which, in developing nations, is universally acquired in infancy. CMV is transmitted in blood, and rarely is a serious infection unless the host is previously immunocompromised (e.g., as in AIDS, or following bone marrow transplantation) or has leukaemia or lymphoma, in which cases CMV may cause severe pneumonia.

TORCH panel

TORCH antibody panel Pediatrics A serologic screen for diagnosing prenatal infection; the finding of ↑ IgM in the neonate implies in utero infection by one of the TORCH agents–toxoplasma, rubella, CMV, herpes simplex, which is then characterized by measuring specific IgM levels.
TORCH agents  
Toxoplasmosis may cause periventricular microglial nodules, thrombosis and necrosis; obstruction of cerebral foramina causes hydrocephalus; with prolonged survival, there is intracranial calcification, hepatocellular, adrenal, pulmonary, cardiac necrosis and extramedullary hematopoiesis
Rubella may cause LBW, hepatosplenomegaly, petechiae and purpura, congenital heart disease, cataracts, microophthalmia and microcephaly; CNS symptoms include lethargy, irritability, dystonia, bulging fontanelles and seizures. See Congenital rubella syndrome.
Cytomegalovirus may cause hepatosplenomegaly, hyperbilirubinemia, neonatal thrombocytopenia, microcephaly and a mortality of 20-30%; later manifestations include mental retardation, deafness, psychomotor delays, dysodontogenesis, chorioretinitis, learning disabilities; ± 33 000 congenital cases/year–US, of which 10% are symptomatic
Herpes simplex may cause prematurity, and becomes symptomatic after the first week of life; CNS symptoms include irritability, seizures, chorioretinitis, hydrocephalus, flaccid or spastic paralysis, opisthotonos, decerebrate rigidity and coma; in neonatal HSV infection, no deaths occur in those with localized disease, 15% die if encephalitis is present and 57% die if HSV is disseminated, potentially evoking DIC NEJM 1991; 324:450
Syphilis–an optional 'TORCH' Congenital syphilis has ↑ to epidemic rates in the urban US since the mid-1980s; the clinical findings are nonspecific and include fever, lethargy, failure to thrive, and irritability  

cy·to·meg·a·lo·vi·rus

(CMV) (sī'tō-meg'ă-lō-vī'rŭs)
A group of herpesviruses infecting humans and other animals, many having special affinity for salivary glands, and causing development of characteristic inclusions in the cytoplasm or nucleus. Most infections are asymptomatic, but if symptoms are present, they manifest as mononucleosislike illness. Congenital infection may cause malformation or fetal death; infection in immunocompromised persons may be life-threatening.
Synonym(s): human herpesvirus 5.
[cyto- + G. megas, big]

Cytomegalovirus (CMV)

A common human virus causing mild or no symptoms in healthy people, but permanent damage or death to an infected fetus, a transplant patient, or a person with HIV.

Patient discussion about Cytomegalovirus

Q. What is it CMV during pregnancy? can i infect with that?

A. CMV is a virus. What you refer to is infection with CMV, either the initial infection, or re-activation of latent (dormant) virus that resides in the mother's body during pregnancy.

The dangers are that CMV will infect the fetus, which may cause malformations, particularly growth restriction and hearing impairment.

You may read more here:
www.nlm.nih.gov/medlineplus/cytomegalovirusinfections.html

Q. What is it CMV during pregnancy ? can i infect with that?

A. CMV or cytomegalovirus (http://en.wikipedia.org/wiki/Cytomegalovirus) is a virus that can cause disease (i.e. infectious mononucleosis, http://en.wikipedia.org/wiki/Infectious_mononucleosis) in everyone, not only pregnant women. The problem is that when a pregnant woman is infected in CMV for the first time of her life during pregnancy, CMV can cause malformations and problems with the baby, including hearing impairment and others (see also TORCHES: http://en.wikipedia.org/wiki/TORCH_infections).

Q. Do you want to end because of a vaccination in a wheel chair? It is already about 12 years ago. I met a mother with her kids. One came always in a wheel chair to the services. His terrible story is still in my mind. It could be shown, that because of a vaccination he got the cytomegalovirus infection (CMV) and then spastic paralysis.

A. Corrigendum: If you know somebody speaking German and English who could...

More discussions about Cytomegalovirus
References in periodicals archive ?
Deficiency of cytomegalovirus (CMV)-specific CD8+ T cells in patients presenting with lateonset CMV disease several years after transplantation.
In this population, we had no high-risk patients for CMV disease (D+/R-) considering CMV IgG antibody serostatus.
CMV DNA was also tested by real time PCR (QIAGEN, Hilden, Germany) monthly in the first 6 months after transplantation, then in every three-months period for one year and/or in case of suspected CMV disease or graft rejection.
CMV disease and kidney transplant: prophylaxis for cytomegalovirus infection in patients following renal transplantation.
One week after GCV discontinuation on D288, she was readmitted for fever recurrence and abdominal pain and a relapse of CMV disease was observed (antigenemia = 20 PC).
The School of Medicine in Cardiff has a well-established background in virology, especially CMV, and is one of only a handful of places in the UK investigating CMV disease.
It is more useful and beneficial for diagnosing CMV infection than CMV antigenemia assay or histological examination and is correlated with the clinical course or severity of CMV disease in organ transplantation or AIDS.
The company said the T-SPOT.CMV test measures the strength of T cell responses to CMV specific antigens; has the potential to assist clinicians with monitoring anti-viral prophylaxis and evaluating patients at risk from CMV disease; leverages its proprietary T-SPOT technology platform; as well as the first in a series of planned new products intended to help transplant patients and physicians manage immune regulated conditions.
[1,2] CMV retinitis is the most common manifestation of end-organ CMV disease among patients with AIDS.
In view of ubiquitous nature of CMV disease 40 chilli genotypes were evaluated against CMV under green house conditions.
Active CMV disease in older patients or in those with compromised immune systems is a devastating disease.