ABCC2

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ABCC2

A gene on chromosome 10q24 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC2 is found in the canalicular (apical) part of hepatocytes and involved in biliary transport. Its substrates include chemotherapeutics (e.g., vinblastine) and thus contributes to drug resistance in humans.
 
Molecular pathology
ABCC2 is mutated in patients with Dubin-Johnson syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
De maneira geral, as medidas de tendencia central, de variabilidade, de assimetria e curtose e o teste de Lilliefors, em relacao aos caracteres morfologicos: altura de planta (AP), numero de racemos por planta (NRP) e comprimento medio dos racemos por planta (CMRP), e aos produtivos: numero de frutos por planta (NFP), numero de frutos por racemo (NFR) e produtividade de graos (PROD), revelaram boa aderencia dos dados, das 75 plantas de crambe (Crambe abyssinica Hochst), a distribuicao normal (Tabela 1).
Caso a opcao seja amostrar 75 plantas, o erro de estimacao seria de [+ or -] 4,49, [+ or -] 5,75, [+ or -] 6,17, [+ or -] 14,33, [+ or -] 10,60 e [+ or -] 14,26% da estimativa da media (m), respectivamente, para os caracteres AP, NRP, CMRP, NFP, NFR e PROD.
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Matt Spurlock (CLS, CMRP, CRL) of Advanced Machine Reliability Resources, Inc.
Additionally, Eric is Six Sigma trained and is a Certified Maintenance and Reliability Professional (CMRP).