CDKN2A

(redirected from CMM2)

CDKN2A

A gene on chromosome 9p21 that encodes an alternate open reading frame (ARF) product, which acts as a tumour suppressor by binding to MDM2 and blocking its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits MDM2’s oncogenic activity, which would normally degrade p53, a tumour suppressor protein. CDKN2A also induces G2 arrest and apoptosis, independent of p53, by preventing the activation of cyclin B1/CDC2 complexes.

CDKN2A also binds to:
• BCL6, downregulating BCL6-induced transcriptional repression;
• E2F1 and MYC, blocking their transcriptional activator activity;
• HUWE1, repressing its ubiquitin ligase activity;
• TOP1/TOPOI, stimulating its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation.

CDKN2A interacts with:
• COMMD1 and promotes its “Lys63”-linked polyubiquitination;
• NPM1/B23, promoting its polyubiquitination and degradation and inhibiting rRNA processing;
• UBE2I/UBC9, enhacing sumoylation of some of its binding partners (e.g., MDM2 and E2F1).
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References in periodicals archive ?
According to the "Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources" (DECIPHER) (4), the 7p13-p12.1 deleted interval contains five genes (GCK, IGFBP-3, OGDH, PPIA, and PSMA2) associated with low haploinsufficiency (HI) score (HI index <10%) (5) and/or high loss intolerance score (pLI [greater than or equal to]0.9) (6) and one intermediate (CMM2: HI 28.18% and pLI 0.48).
of questions Factor type loading w Hedonic HMl .95 [alpha] = .96 motivation HM2 .94 CR = .96 HM3 .93 AVE = .88 Utilitarian UM1 .96 [alpha] = .93 motivation UM2 .98 CR = .93 UM3 .77 AVE = .82 Compliance CMM1 .97 [alpha] = .96 motivation CMM2 .98 CR = .96 CMM3 .90 AVE = .90 Conformity CNM1 .95 [alpha] = .95 motivation CNM2 .90 CR = .95 CNM3 .93 AVE = .86 Affiliation AMI .87 [alpha] = .91 motivation AM2 .88 CR = .91 AM3 .88 AVE = .77 Construct No.