CMF regimen | definition of CMF regimen by Medical dictionary
CMF regimen Oncology An adjuvant combination–cyclophosphamide, MTX, fluorouracil–regimen administered after modified radical mastectomy in lymph node-positive breast CA. See Breast cancer.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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* The CMF regimen
involves cyclophosphamide 100 mg/[m.sup.2] given orally on days 1-14; methotrexate in doses of 40 mg/[m.sup.2] via IV on days 1 and 8; and 5-fluorouracil 600 mg/[m.sup.2] given by IV on days 1 and 8, repeated every 28 days for a total of six cycles.
Darby and his colleagues looked at a total of 30 women who had already undergone either lumpectomy or mastectomy and were scheduled to undergo either the chemotherapy regimen known as AC (n = 15) or CEF or CMF regimens
(n = 15).
The second wave of trials compared anthracycline-based regimens with CMF regimens
. The relative risk of recurrence was reduced by a further 16% with anthracycline regimens, compared with CMF, in women younger than 50, and by 11% in those aged 50-69.