clusterin(redirected from CLU.)
a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions; its expression is enhanced in tissue injury and remodeling as well as in degenerative diseases such as alzheimer's disease.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Heterodimeric highly conserved secreted glycoprotein, which is expressed in a wide variety of tissues and found in all human fluids; implicated in physiologic processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis.
Synonym(s): apolipoprotein J
Farlex Partner Medical Dictionary © Farlex 2012
clusterin(klus'te-rin) [ cluster + -in],
A multifunctional cell-protective glycoprotein (molecular weight 75-80 kDa) found in many tissues. High levels of CLU are found in cells undergoing apoptosis. Synonym: apolipoprotein J
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