CLEC12A

(redirected from CLL1)

CLEC12A

A gene on chromosome 12p13.2 that encodes a C-type lectin domain receptor which modulates signalling cascades and mediates tyrosine phosphorylation of target MAP kinases.
References in periodicals archive ?
The company and others have shown that CLL1 is expressed in approximately 90% of all AML patient types, including all French American British classifications, all cytogenetic risk categories, and in patients independent of FLT-3 status.
Importantly, CLT030-ADC should have minimal effect on the formation of normal blood cell types because CLL1 is not expressed on normal hematopoietic stem cells and minimally on progenitor cells.