MMP8

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MMP8

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 8, which degrades fibrillar type I, II and III collagens. It is involved in breaking down extracellular the matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members in that it is stored in secondary granules within neutrophils and activated by autolytic cleavage.

Molecular pathology
Defects in MMP8 have been linked to arthritis and metastasis.
References in periodicals archive ?
[2] In other words, we examine a type set, C1G1 here, for internal rule-1 relationships as a result of rule 2, i.e., we look for types that are identical with respect to pitch-class content but are arranged in different dyad configurations (which means that the same pitch-class collection can be arranged in more than one ClG1 configuration).
For example, we might look for types in ClG3 that are (pitch-class equivalent) duplications of types generated by ClG1: (the notation "unique to ClG1" means unique to ClG1 only with respect to the type set the latter is being compared to, in this case, ClG3, not necessarily unique in its own type set or with respect to other type sets).