CLEC6A | definition of CLEC6A by Medical dictionary
CLEC6A A gene on chromosome 12p13 that encodes a C-type lectin domain protein involved in Ca2+-dependent binding of high-mannose carbohydrates present on the surface of Candida albicans, dust mites and Schistosoma mansoni eggs, altering the adaptive immune response.
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References in periodicals archive
The binding of mycobacterial PAMPs to their receptors, CLEC7A, CLEC6A
, or CLEC4E, stimulates Syk activation in their signal transduction , and Syk knock-out mice show attenuated antibacterial host defense .
Dectin-2 (or DCAL-2, Clec6A) or beta-glucan receptor is a C-type lectin receptor expressed on DCs, macrophages, neutrophils, and monocytes (Table 1) .
DCAL-2 Expressed on DCs, macrophages neutrophils, Dectin-2 Clec6A and monocytes.