CLEC5A | definition of CLEC5A by Medical dictionary
CLEC5A A gene on chromosome 7q33 that encodes a C-type lectin domain protein that regulates osteoclastogenesis and inflammation.
CLEC5A plays a central role in synovial and joint injury in autoimmune arthropathy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
Phillips et al., "Activation of MDL-1 (CLEC5A
) on immature myeloid cells triggers lethal shock in mice," Journal of Clinical Investigation, vol.
(70) In fact, the ASXL1-MT inhibition of G-SCF-induced granulocytic differentiation of 32D cells was rescued by Clec5a
The binding of dengue virus to its receptor, CLEC5A
, activates Syk and induces the production of proinflammatory cytokines through the binding of Syk with phosphorylated DAP12, which is an adaptor molecule between CLEC5A
and Syk .