CLEC5A

CLEC5A

A gene on chromosome 7q33 that encodes a C-type lectin domain protein that regulates osteoclastogenesis and inflammation.

Molecular pathology
CLEC5A plays a central role in synovial and joint injury in autoimmune arthropathy.
References in periodicals archive ?
Phillips et al., "Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice," Journal of Clinical Investigation, vol.
(70) In fact, the ASXL1-MT inhibition of G-SCF-induced granulocytic differentiation of 32D cells was rescued by Clec5a expression.
The binding of dengue virus to its receptor, CLEC5A, activates Syk and induces the production of proinflammatory cytokines through the binding of Syk with phosphorylated DAP12, which is an adaptor molecule between CLEC5A and Syk [73].