CLEC4M | definition of CLEC4M by Medical dictionary
CLEC4M A gene on chromosome 19p13 that encodes a pathogen-recognition receptor expressed on the surface of immature dendritic cells which is involved in initiating a primary immune response. The receptors are thought to recognise high-mannose N-linked oligosaccharides present on the surface of pathogens (such as HIV-1, HIV-2 and SIV gp120, among others) in a calcium-dependent fashion. Once bound, the receptor mediates endocytosis of the pathogens, which are subsequently degraded in lysosomal compartments. The receptor then returns to the cell membrane surface, and the pathogen-derived antigens are presented to resting T cells via MHC class-II proteins to initiate the adaptive immune response.
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References in periodicals archive
Three major attachment factors for Flavivirus are heparin sulfates, dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN, CD209 antigen), and DC-SIGNR (CLEC4M), which interact with N-linked glycans of the viral E glycoprotein.
Both E and M ZIKV proteins establish PPIs with a score 0.2 with DC-SIGN and with the C-type lectin domain family 4 member M (CLEC4M), a L-SIGN type receptor for mannose-like carbohydrates .
L-SIGN or DC-SIGNR (also known as CD299, CD209L, and Clec4M
) is a type-II transmembrane C-type lectin receptor homologous to DC-SIGN (77% amino acid sequence homology), highly expressed on liver sinusoidal cells, endothelial vascular cells, and in the lymph nodes, but not on DCs, in contrast to DC-SIGN (Table 1 and Figure 1).