CD209

(redirected from CLEC4L)

CD209

A gene on chromosome 19p13 that encodes a pathogen-recognition receptor expressed on the surface of immature dendritic cells which is involved in initiating a primary immune response. These receptors are thought to recognise high mannose N-linked oligosaccharides present on the surface of pathogens (such as HIV-1, HIV-2 and SIV gp120, amongst others) in a calcium-dependent fashion. Once bound, the receptor mediates endocytosis of the pathogens, which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface, while the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
References in periodicals archive ?
Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin, (DC-SIGN) also known as CD209, Clec4L, is a C-type membrane lectins abundantly expressed on immature DCs, macrophages, endothelial vascular cells, atherosclerotic plaques, and lymphatic vessels, but not on plasmacytoid DCs (Table 1 and Figure 1).
CD209 Expressed on immature DCs, macrophages Dendritic Clec4L endothelial vascular cells, atherosclerotic cell- plaques, and lymphatic vessels, not on specific placmacytoid DCs.