CLEC4E

CLEC4E

A gene on chromosome 12p13.31 that encodes a C-type lectin domain protein which acts as a cell surface receptor for an array of ligands, including damaged cells (e.g., SAP130, a nuclear protein released by dying cells), fungi (e.g., alpha-mannose residues on the genus Malassezia) and mycobacteria (e.g., trehalose 6,6’-dimycolate (TDM), a cell wall glycolipid). CLEC4E transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain (FCER1G) and
induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappaB.
References in periodicals archive ?
Gene Network node IL-6 30 ETS2 29 TNF 25 OPN1MW 21 IFNAL 19 STAT1 18 SMAD1 18 EGR1 18 JUNb 17 IL-1b 16 STAT3 14 NF-kappa B 14 STAT2 13 JUN 13 FOS 13 TP53 12 TNF[alpha] 12 PTX3 12 PTGS2 12 PPARD 12 KYNU 12 IRF6 12 IL-8 12 CXCL16 12 CLEC4E 12 ATF3 12 STAT4 11 SNAI2 11 SNAIL 11 SMAD3 11 SLC2A1 11 RELA 11 REC8 11 PINX1 11 NOL3 11 MCM2 11 ILDHA 11 IGFBP3 11 GADD45G 11 G6PD 11 SP3 10 SMAD2 10 RELB 10 IL-5 10 Table 5: GO function annotation of differentially expressed genes.
The binding of mycobacterial PAMPs to their receptors, CLEC7A, CLEC6A, or CLEC4E, stimulates Syk activation in their signal transduction [71], and Syk knock-out mice show attenuated antibacterial host defense [72].
The ligands produced by necrotic cells bind to their receptors, such as CLEC4E associated with Fc[gamma]R or CLEC9A, resulting in the recruitment and activation of Syk [74-76].