CLEC2D | definition of CLEC2D by Medical dictionary
CLEC2D A gene on chromosome 12p13 that encodes the receptor for KLRB1, which binds high-molecular-weight sulfated glycosaminoglycans and protects target cells against natural killer cell-mediated lysis. CLEC2D inhibits osteoclast formation, and by extension, bone resorption, and modulates the release of interferon-gamma.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
In this regard, 14 genes involved in NK activity were modulated in NCGS samples (i.e., LILRA1, LILRA2, CLEC2D
, and KLRC4).
Amouri et al., "Association of ZAP70 and PTPN6, but not BANK1 or CLEC2D
, with inflammatory bowel disease in the tunisian population," Genetic Testing and Molecular Biomarkers, vol.