CLEC1B

CLEC1B

A gene on chromosome 12p13.2 that encodes a C-type lectin domain protein which acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding triggers tyrosine phosphorylation, spleen tyrosine kinase (Syk) binding, downstream tyrosine phosphorylation and activation of PLC-gamma-2. CLEC1B acts as an attachment factor for HIV-1, facilitating its capture by platelets. It is expressed in the liver, myeloid cells and on platelets.
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Another gene, CLEC1B (rank 16 in the mRMR feature list), also participates in the development of IBD via the regulation of the intestinal immune system, especially the proliferation of NK cells and the formation of lymph nodes [114].
CLEC2 (also known as Clec1B), a C-type lectin-like receptor 2, is expressed on NK cells, DCs, monocytes, granulocytes, platelets, megakaryocytes, and liver sinusoidal endothelial cells (Table 1) 157].
C- Clec1B Expressed on NK cells, monocytes, type granulocytes, platelets, megakaryocytes, lectin-like and liver sinusoidal epithelial cells.