CLEC17A | definition of CLEC17A by Medical dictionary
CLEC17A A gene on chromosome 19p13.12 that encodes a C-type lectin domain protein which is a cell surface receptor possibly involved in carbohydrate-mediated communication between cells in the germinal centre. CLEC17A binds glycans with terminal alpha-linked mannose or fucose residues. It is expressed on dividing B-cells of germinal centres in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen.
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References in periodicals archive
Novel membrane-associated proteins including cytoskeleton-associated protein 4 (CKAP4), polymeric immunoglobulin receptor (PIGR), transmembrane and coiled-coil domain protein 3 (TMCC3) and CD75; and others that are involved in BCR signaling like lymphocyte transmembrane adapter 1 (LAX1), C-type lectin domain family 17 member A (CLEC17A
) and plasma membrane calcium-transporting ATPase 4 (ATP2B4); were also reported with elevated expression in the CLL samples.