CLEC12B

CLEC12B

A gene on chromosome 12p13.2 that encodes a C-type lectin domain receptor which protects target cells against NK cell-mediated lysis, modulates signalling cascades and mediates tyrosine phosphorylation of target MAP kinases.
References in periodicals archive ?
CLEC12B. CLEC12B (macrophage antigen H) is part of the NK gene complex/Dectin-1 cluster of C-type lectin receptors, highly expressed on macrophages, monocytes, and DCs and contains immunoinhibitory sequences in its cytoplasmic tail [161, 162].
Textor et al., "Identification of CLEC12B, an inhibitory receptor on myeloid cells," Journal of Biological Chemistry, vol.
Clec21B Part of the NK gene comp[Le.sup.x]/dectin-1 CLEC12B cluster of C-type lectin receptors.