Brown, "Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand," European Journal of Immunology, vol.
Clec12A Homologous to Dectin-1 and part of Dectin-1 Myeloid cluster.
MICL (myeloid inhibitory C-type lectin-like receptor, Clec12A) is homologous to Dectin-1 and is part of the Dectin-1 cluster 152].
CLT030 targets C-type-like lectin 1 (CLL1, also known as CLEC12A
), a cell surface antigen expressed in nearly all AML cell subtypes, including leukemic stem cells, but not on normal hematopoietic stem cells.
The team screened these proteins to identify two (CLEC12A and CD64) that could be used as markers depending on high and low levels of expression.
One of these subgroups was a population of cells expressing high levels of both CLEC12A and CD64.
Downregulation/deficiency of C-type lectin domain family 12, member A (CLEC12A
), a C-type lectin-like pattern recognition receptor, is associated with hyperinflammatory responses.
MCLA-117 (CLEC12A x CD3 Biclonics): Expect to present initial Phase 1 data at a medical conference 1H 2020.
MCLA-117 is a Biclonics that binds with relative low affinity to CD3, a component of the T cell receptor present on all T cells, and relative high affinity to CLEC12A, a cell surface molecule present on acute myeloid leukemia ('AML') tumor cells and AML stem cells.