CLEC11A

CLEC11A

A gene on chromosome 19q13.3 that encodes a C-type lectin domain protein expressed in bone, cartilage and bone marrow, which stimulates the proliferation and differentiation of haematopoietic stem cells. CLEC11A acts synergistically with other cytokines, such as IL3, GCSF, GMCSF and FLT3 ligand. CLEC11A suppresses SCF-stimulated erythrocyte proliferation.
References in periodicals archive ?
Among these CpGs, one (cg10773601) was annotated to <1,500 bps from the transcription start site of C-Type Lectin Domain Family 11, Member A (CLEC11A).
Interestingly, we found that in utero lead exposure was associated with altered methylation levels at CpGs located within or near important regulatory genes of hematopoietic and nervous functions (i.e., CLEC11A and DNHD1).
DALLAS, Texas, December 13, 2016 -- Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered a new bone-forming growth factor, osteolectin (Clec11a), which reverses osteoporosis in mice and has implications for regenerative medicine.