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leukoencephalopathy with vanishing white matter

A leukodystrophy of childhood onset (OMIM:603896) characterised by progressive cerebellar ataxia, spasticity, variable optic atrophy and relatively preserved mental abilities. Leukodystrophy with vanishing white matter is usually slowly progressive, but may undergo rapid deterioration after fever or minor head trauma. Clinical variants include a severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba (Cree leukoencephalopathy), and a milder form affecting females who survive to adolescence and exhibit ovarian dysfunction (ovarioleukodystrophy).

Molecular pathology
Defects in EIF2B1, which encodes a subunit of eukaryotic translation initiation factor 2B (EIF2B), an essential regulator of protein synthesis, are a cause of leukodystrophy with vanishing white matter.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Patient discussion about CLE

Q. Cn barret esophagous be cured? I was diagnosed with barretts esophagus several years ago, and so far keeps on the routine follow up. I met some other guy with same condition and he told after his doctor prescribed him with some anti-reflux meds, in the last endoscopy they found normal esophagus, and that he thinks he's now cured. Is that possible?

A. Anti-reflux treatment may lower the risk of cancer a little, but it won't cure it, so there's still a need for refular follow-up.

More discussions about CLE
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References in periodicals archive ?
(25) Endoscope-based CLE has been shown to accurately differentiate normal epithelium from metaplasia and dysplasia.
Asked if the observed increase in cancer linked with CLE is caused by the skin disease itself, or instead the immunosuppressive therapies employed in its treatment, Dr.
There were no fluorescein-related complications, but pneumonia developed in one patient who underwent CLE.
Bronchoscopy in the diagnosis of CLE is controversial, although it should be used to exclude foreign body aspiration in suspected cases.
In addition, CLE also provides around-the-clock legal advice and helpline services, plus outsourcing support for third party insurers and service providers.
* Generations Conversations--This group is partnering with YLD and the Standing Committee on Diversity and Inclusion to develop programs addressing the issue of generational diversity and commonality, encompassing both unstructured social conversation and CLE programming.
But if a "distinguished senior lawyer" no longer has an office and is not practicing, then there are few if any Bar benefits to be enjoyed and no need to take CLE courses on subjects no longer of interest.
CLE has no approved treatments in the United States.
Dallas, TX, May 03, 2015 --( Klemchuk LLP, a leading intellectual property (IP) law firm, announces its 11th annual Ethics CLE. The event will be held on Friday, May 15, 2015 in Dallas and offers guests 90 minutes of ethics CLE credit in a fun and casual environment.
Attendance at courses taught by TJAGLCS faculty at locations other than Charlottesville, VA, must be self-reported by attendees to the extent and manner provided by their individual state CLE program offices.
The population-based study, which included all 1,088 patients diagnosed with CLE in Sweden from 2005 to 2007, found that the risk of being diagnosed with SLE during the first year of CLE diagnosis was 12%.
BAA Cleveland Inc, the developer and manager of the retail and concessions programme at Cleveland Hopkins International Airport (CLE), announced on Monday that the first two units of the new food court at the new AIRMALL at CLE have been opened.