ZO-1=zonula occludens 1; CLDN5
= claudin 5; OCLN = occludin; JAM-3 = junctional adhesion molecule 3; CTNNB1 = catenin-[beta]1.
ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5
Interestingly, expression of occludin (OCLN) and claudin-5 (CLDN5
), the primary proteins comprising tight junctions , was not significantly different between model systems.
Additionally, skin barrier genes, such as CLDN5
and CLDN7, were dysregulated, indicating skin injury in CAD development.
: claudin-5, COX: cyclooxygenase, CRP: C-reactive protein, Fcy receptor: fragment crystallizable region, ICAM1: intracellular adhesion molecule-1, IL: interleukin, NADPHox: nicotinamide adenine dinucleotide phosphate oxidase, NF[kappa]B: nuclear factor kappa-light-chain-enhancer, MMP: matrix metalloproteinase, MLC: myosin light chain, MLCK: myosin light chain kinase, PGE: prostaglandin, PKC: protein kinase C, sICAM: soluble ICAM, sTNF-[alpha]R: soluble TNF-[alpha] receptor, VEGF: vascular endothelial growth factor, TNF: tumor necrosis factor, and ZO: zonula occludens.
The mRNA expressions of occludin (Ocln), ZO-1 (Tjp1), claudin-1 (Cldn1), claudin-5 (Cldn5), ICAM-1 (ICAM1), TNF[alpha] (Tnf), IL-6 (Il6), IL-1[beta] (Il1b), and actin (Actb) were quantified by real-time PCR.
The retinal mRNA expressions of occludin (Olcn), ZO-1 (Tjp1), claudin-1 (Cldn1), and claudin-5 (Cldn5) were decreased in STZ-induced diabetic rats (P < 0.05, P < 0.05, P < 0.01, and P < 0.01, resp.).
Although my tests did not indicate that I had celiac disease, a genetic test taken later revealed that 1 have the HLA-DQB1 gene, which is linked (along with the CLDN5
gene) to gluten-induced schizophrenia.
Hemmer, "TNF-[alpha]lpha induced NF[kappa]B signaling and p65 (RelA) overexpression repress Cldn5
promoter in mouse brain endothelial cells," Cytokine, vol.
Other genes identified in precursor lesions include PENK, CDKN2A/p16, STK11/LKB1, SPARC, SFRP1/SARP2 (chromosome arm 8p), TSLC1, RELN (chromosome arm 7q), TFPI2, CLDN5
(chromosome arm 22q), and UCHL1 in IPMNs (37,122,123); PENK, CDKN2A/p16, CLDN5
, NPTX2, RPRM, SFRP1/SARP2, and LHX1 (chromosome arm 11p) in PanINs (117,118,124); and CDKN2A/p16 in MCNs.