CLDN5

A gene on chromosome 22q11.21 that encodes claudin-5, an integral membrane protein of the claudin family, the members of which form a physical physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
CLDN5 mutations are linked to velocardiofacial syndrome.

References in periodicals archive ?

ZO-1=zonula occludens 1; CLDN5 = claudin 5; OCLN = occludin; JAM-3 = junctional adhesion molecule 3; CTNNB1 = catenin-[beta]1.

Molecular Responses of Human Retinal Cells to Infection with Dengue Virus

ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene.

Application of Immunohistochemistry in Undifferentiated Neoplasms: A Practical Approach

Interestingly, expression of occludin (OCLN) and claudin-5 (CLDN5), the primary proteins comprising tight junctions [21], was not significantly different between model systems.

Gene Expression Changes in Long-Term In Vitro Human Blood-Brain Barrier Models and Their Dependence on a Transwell Scaffold Material

Additionally, skin barrier genes, such as CLDN5 and CLDN7, were dysregulated, indicating skin injury in CAD development.

Genome-Wide Analysis of mRNA and Long Noncoding RNA Profiles in Chronic Actinic Dermatitis

Cldn5: claudin-5, COX: cyclooxygenase, CRP: C-reactive protein, Fcy receptor: fragment crystallizable region, ICAM1: intracellular adhesion molecule-1, IL: interleukin, NADPHox: nicotinamide adenine dinucleotide phosphate oxidase, NF[kappa]B: nuclear factor kappa-light-chain-enhancer, MMP: matrix metalloproteinase, MLC: myosin light chain, MLCK: myosin light chain kinase, PGE: prostaglandin, PKC: protein kinase C, sICAM: soluble ICAM, sTNF-[alpha]R: soluble TNF-[alpha] receptor, VEGF: vascular endothelial growth factor, TNF: tumor necrosis factor, and ZO: zonula occludens.

Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link

The mRNA expressions of occludin (Ocln), ZO-1 (Tjp1), claudin-1 (Cldn1), claudin-5 (Cldn5), ICAM-1 (ICAM1), TNF[alpha] (Tnf), IL-6 (Il6), IL-1[beta] (Il1b), and actin (Actb) were quantified by real-time PCR.

The retinal mRNA expressions of occludin (Olcn), ZO-1 (Tjp1), claudin-1 (Cldn1), and claudin-5 (Cldn5) were decreased in STZ-induced diabetic rats (P < 0.05, P < 0.05, P < 0.01, and P < 0.01, resp.).

Dendrobium chrysotoxum Lindl. Alleviates diabetic retinopathy by preventing retinal inflammation and tight junction protein decrease

Although my tests did not indicate that I had celiac disease, a genetic test taken later revealed that 1 have the HLA-DQB1 gene, which is linked (along with the CLDN5 gene) to gluten-induced schizophrenia.

'Why don't they just get a job?' Potential solutions for the chronically homeless

Hemmer, "TNF-[alpha]lpha induced NF[kappa]B signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells," Cytokine, vol.

Alterations of blood-brain barrier and associated factors in acute liver failure

Other genes identified in precursor lesions include PENK, CDKN2A/p16, STK11/LKB1, SPARC, SFRP1/SARP2 (chromosome arm 8p), TSLC1, RELN (chromosome arm 7q), TFPI2, CLDN5 (chromosome arm 22q), and UCHL1 in IPMNs (37,122,123); PENK, CDKN2A/p16, CLDN5, NPTX2, RPRM, SFRP1/SARP2, and LHX1 (chromosome arm 11p) in PanINs (117,118,124); and CDKN2A/p16 in MCNs.