CLDN5

CLDN5

A gene on chromosome 22q11.21 that encodes claudin-5, an integral membrane protein of the claudin family, the members of which form a physical physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
CLDN5 mutations are linked to velocardiofacial syndrome.
References in periodicals archive ?
ZO-1=zonula occludens 1; CLDN5 = claudin 5; OCLN = occludin; JAM-3 = junctional adhesion molecule 3; CTNNB1 = catenin-[beta]1.
ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene.
Interestingly, expression of occludin (OCLN) and claudin-5 (CLDN5), the primary proteins comprising tight junctions [21], was not significantly different between model systems.
Additionally, skin barrier genes, such as CLDN5 and CLDN7, were dysregulated, indicating skin injury in CAD development.
Cldn5: claudin-5, COX: cyclooxygenase, CRP: C-reactive protein, Fcy receptor: fragment crystallizable region, ICAM1: intracellular adhesion molecule-1, IL: interleukin, NADPHox: nicotinamide adenine dinucleotide phosphate oxidase, NF[kappa]B: nuclear factor kappa-light-chain-enhancer, MMP: matrix metalloproteinase, MLC: myosin light chain, MLCK: myosin light chain kinase, PGE: prostaglandin, PKC: protein kinase C, sICAM: soluble ICAM, sTNF-[alpha]R: soluble TNF-[alpha] receptor, VEGF: vascular endothelial growth factor, TNF: tumor necrosis factor, and ZO: zonula occludens.
The mRNA expressions of occludin (Ocln), ZO-1 (Tjp1), claudin-1 (Cldn1), claudin-5 (Cldn5), ICAM-1 (ICAM1), TNF[alpha] (Tnf), IL-6 (Il6), IL-1[beta] (Il1b), and actin (Actb) were quantified by real-time PCR.
The retinal mRNA expressions of occludin (Olcn), ZO-1 (Tjp1), claudin-1 (Cldn1), and claudin-5 (Cldn5) were decreased in STZ-induced diabetic rats (P < 0.05, P < 0.05, P < 0.01, and P < 0.01, resp.).
Although my tests did not indicate that I had celiac disease, a genetic test taken later revealed that 1 have the HLA-DQB1 gene, which is linked (along with the CLDN5 gene) to gluten-induced schizophrenia.
Hemmer, "TNF-[alpha]lpha induced NF[kappa]B signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells," Cytokine, vol.
Other genes identified in precursor lesions include PENK, CDKN2A/p16, STK11/LKB1, SPARC, SFRP1/SARP2 (chromosome arm 8p), TSLC1, RELN (chromosome arm 7q), TFPI2, CLDN5 (chromosome arm 22q), and UCHL1 in IPMNs (37,122,123); PENK, CDKN2A/p16, CLDN5, NPTX2, RPRM, SFRP1/SARP2, and LHX1 (chromosome arm 11p) in PanINs (117,118,124); and CDKN2A/p16 in MCNs.