CLDN2A gene on chromosome Xq22.3-q23 that encodes claudin-2, an integral membrane protein of the claudin family, which form part of tight junction strands, providing a continuous seal around cells and serving as a physical barrier to prevent solutes and water from passing freely into the interstitial space. Claudins play critical roles in maintaining cell polarity and signal transduction. Claudin-2 is expressed in the intestine.
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