CLDN12

CLDN12

A gene on chromosome 7q21 that encodes claudin-12, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction. Claudin-12 is expressed in the inner ear and bladder epithelium. 

Molecular pathology
CLDN12 is overexpressed in colorectal carcinoma.
References in periodicals archive ?
Specifically, PET cultures were observed to have significantly higher expression of SPARC (p = 0.022), laminin subunit [alpha]2 (LAMA2, p = 0.006), LIF (p = 0.045), fibroblast growth factor 2 (FGF2, p = 0.029), claudin 12 (CLDN12, p = 0.003), tight junction protein 1 (TJP1, p = 0.008), gap junction [alpha]1 protein (GJA1, p = 0.049), and vascular cell adhesion molecule 1 (VCAM1, p < 0.001).
Expression levels of all endothelial tight junction transmembrane proteins assayed were equal between the biopaper and PET coculture models at all time points, with the exception of CLDN12 and CLDN1.