CLCN4

CLCN4

A gene on chromosome Xp22.3 that encodes a voltage-gated chloride channel. CLCN4 has an evolutionary conserved CpG island, and maps close to apical protein Xenopus laevis (APXL)-like and ocular albinism type I (OA1), which are both located on Xp22.3. Its physiologic role is unknown, but may be linked to neuronal disease.
References in periodicals archive ?
Therefore, other candidate genes are postulated such as CLCN4, CFL1, SLC9A6 and TMEM27 [2].
To confirm the detected changes in transcript levels between the H and L groups (n = 3), we quantified the expression level of 8 genes (identified via RNA-Seq) selected from the DEGs: peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B), secreted phosphoprotein 2 (SPP2), stearoyl-CoA desaturase 5 (SCD5), myogenic differentiation (MyoD), chloride channel 4 (CLCN4), collagen, type I, alpha 1 (COL1A1), myogenin (MyoG), and stearoyl-CoA desaturase (SCD).
Three genes with relevant functions in lipid metabolism (SCD5, SCD, and PPARGC1B), 2 with a relevant functions in myogenesis (MYOD1 and MYOG), one related to fibrogenesis (COL1A1), one showing high expression levels in Y2 (CLCN4) and one showing high expression in Y1 (SPP2), were subjected to quantification by RT-PCR.