CCR5

(redirected from CKR5)
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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
References in periodicals archive ?
Genetic resistance of HIV infection and progression to AIDS by deletion of the CKR5 structural gene.
A double dose of the mutated gene, called CKR5, confers complete immunity to AIDS, the researchers said.
Since about 600 people in the study never became infected with HIV, the researchers report, the CKR5 mutation, as prevalent as it is, accounted for only 3 percent of the resistance.