CCR5

(redirected from CKR5)
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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
References in periodicals archive ?
CCR5 (CKR5; sc-6128) antibody was purchased from Santa Cruz Biotechnology (Whitehead Scientific, SA).
We know, for instance, that the immune cells of persons who inherit the otherwise unremarkable absence of the cell-surface protein CKR5 cannot be infected by HIV.
Este sitio en 3p21 fue posteriormente identificado como el locus cromosomico donde se ubica el gen CKR5 el cual codifica para un receptor secundario en el linfocito T del VIH-1.